Searchable abstracts of presentations at key conferences in endocrinology

ea0010p51 | Neuroendocrinology and behaviour | SFE2005

Pituitary adenylate cyclase activating polypeptide (PACAP) and histone H2AZ: novel SF-1 target gene in the ventromedial hypothalamus (VMH)?

Fowkes R , Tran P , Kurrasch D , Ingraham H

The transcription factor, Steroidogenic factor-1 (SF-1/NR5A1) is the only specific marker of the VMH, to date. Total SF-1 deficiency results in defective VMH neuronal differentiation and architecture, and mice heterozygous for SF-1 (SF-1+/−), or conditionally depleted of SF-1 in the VMH show reduced levels of the neurotrophin Bdnf and an increased propensity for weight gain. Recent studies have suggested several putative SF-1 target genes in the VMH tha...