Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1734 | Thyroid (non-cancer) | ICEECE2012

The influence of chronic stimulation of thyrotropin on nodular thyroid goiter

Medenica S. , Trbojevic B. , Ciric J. , Beleslin B. , Stojkovic M.

Introduction: Nodular goiter is clinically recognizable restricted structure changes of the thyroid gland. FNA is the first line diagnostic test for an enlarged thyroid gland. TSH is known as a thyroid growth factor, but the pathogenic role of this hormone in thyroid oncogenesis is unclear.Objective: The aim of this study is to analyze the relationship between elevated serum TSH concentrations and thyroid malignancies in patients with nodular thyroid goi...

ea0029p434 | Clinical case reports - Thyroid/Others | ICEECE2012

Primary hyperparathyroidism associated with autoimmune polyglandular syndrome type III and isolated IgA deficiency

Savic S. , Zarkovic M. , Ciric J. , Beleslin B. , Stojkovic M. , Nisic T. , Stojanovic M. , Trbojevic B.

Introduction: Isolated IgA deficiency (SIgAD) is the most common form of primary immunodeficiency. Patients with SIgAD have an increased risk of both systemic and organ-specific autoimmune diseases. Autoimmune thyroid diseases (AITD) and type 1 diabetes mellitus (T1DM) are the most common autoimmune endocrine disorders. They occur frequently together, and this combination is nominated as autoimmune polyglandular syndrome type 3 (APS 3). Primary hyperparathyroidism (PHPT) is th...

ea0029p980 | Female Reproduction | ICEECE2012

Differences in gonadal axis reaction to ketoconasole between PCOS and healthy individuals

Stojkovic M. , Savic S. , Beleslin B. , Ciric J. , Trbojevic B. , Zarkovic M.

Background: Ketoconazole is a synthetic antifungal drug, and powerful inhibitor of steroidogenesis. Oral ketoconazole blocks both ovarian and adrenal androgen biosynthesis, and glucocorticoid synthesis, leading to a reduction in circulating testosterone and cortisol levels. In subjects with an intact HPA axis, ketoconazole by decreasing cortisol levels leads to compensatory rise an ACTH level.Objectives: To assess influence ketoconasole induced changes i...

ea0011p341 | Diabetes, metabolism and cardiovascular | ECE2006

Lipid profile in normal weight and obese women with polycystic ovary syndrome

Stojkovic M , Zarkovic M , Ciric J , Beleslin B , Savic S , Drezgic M , Trbojevic B

Background: Women with polycystic ovary syndrome (PCOS) appear at increased cardiovascular risk due in part to a dyslipidemia characterized by increased plasma triglyceride and reduced high density lipoprotein (HDL) cholesterol levels. Obesity, insulin resistance and hyperandrogenemia are features of PCOS and potentially affect lipid metabolism. On the other hand, obesity has an important influence on the lipid metabolism.Objectives: The aim of this stud...

ea0011p494 | Endocrine tumours and neoplasia | ECE2006

Daily profiles of aldosterone secretion in primary aldosteronism

Ciric J , Zarkovic M , Beleslin B , Penezic Z , Stojkovic M , Savic S , Trbojevic B

In supine subjects aldosterone daily variations are determined by spontaneous PRA rhythmicity and ACTH secretory bursts. The aim of this study was to analyze diurnal and pulsatile aldosterone secretion in two patients with primary aldosteronism (PA): a 33-year-old woman with aldosterone producing adenoma (APA) and a 40-year-old woman with idiopathic adrenal hyperplasia (IAH). Blood samples were taken hourly during 24 hours at the time of the diagnosis and three months later, a...

ea0011p623 | Neuroendocrinology and behaviour | ECE2006

Influence of affective changes on cortisol response to ACTH

Zarkovic M , Ciric J , Beleslin B , Penezic Z , Stojkovic M , Savic S , Trbojevic B

In this study we wanted to assess whether affective changes influence cortisol response during low dose (1 microgram) ACTH test. Beck Inventory of Depression and Hamilton Anxiety Rating Scale and low dose ACTH test were performed in five subjects during the prolonged psychological stress induced by war and 18 months later. After the war, Beck Inventory of Depression and Hamilton Anxiety Rating Scale scores were significantly reduced. Suppression of the HPA axis was present dur...

ea0011p761 | Steroids | ECE2006

Rapid glucocorticoid effects on insulin sensitivity

Beleslin BZ , Ciric J , Stojkovic M , Savic S , Penezic Z , Trbojevic B , Zarkovic M

Background: Although it is well known that glucocorticosteroids induce insulin resistance, probably due to postreceptor defects, the exact time scale is still a matter of debate.Objective: The aim of the present study was to determine the time scale of effects of therapeutic doses of glucocorticoids on insulin sensitivity.Methods: Study group consisted of 20 patients with Graves ophtalmopathy who were treated with corticosteroids f...