Searchable abstracts of presentations at key conferences in endocrinology

ea0028p323 | Steroids | SFEBES2012

Mitogen mediated Gc resistance, development of model using serum shock

Yang Nan , Trebble Peter , Matthews Laura , Ray David

Glucocorticoids (Gc) are the most potent anti-inflammatory agents known. A major factor limiting their clinical use is the wide variation in responsiveness to treatment between individuals and over time. Generating a reversible model of Gc resistance in vitro that will mimic the cellular microenvironment in vivo is critical in (i) defining biomarkers that predict patient steroid responsiveness; (ii) provide a model to screen new GR modulators capable of potentiating GR ...

ea0025oc2.6 | Steroids | SFEBES2011

Novel non-steroidal glucocorticoids that dissociate rapid signalling effects from gene transcription

Trebble Peter , Simpson Karen , Matthews Laura , Farrow Stuart , Ray David

Glucocorticoids (GCs) are used extensively in the treatment of inflammatory disease. Unfortunately, as GC act on virtually every organ system they also carry a broad range of serious side-effects which limits their clinical use.The structure of the bound GC strongly impacts the final conformation of the glucocorticoid receptor (GR) and thereby dictates downstream events. Designing drugs with different GR binding properties therefore offers a plausible ro...