Endocrine Abstracts

Introduction: The BsmI restriction fragment polymorphism of the vitamin D receptor (VDR) has been related with the development of bone disease in postmenopause, homozygous β thalassemia and hyperthyroidism. The present study aimed to evaluate the association between bone metabolism in patients with epilepsy and the BsmI VDR’s polymorphism.Methods/design: This cross-sectional study evaluated 73 adult patients with epilepsy, under antiepileptic d...

Introduction: Anti-epileptic drugs, usually defined according to their effect on the cytochrome P450 system, might lead to bone mineral density (BMD) decrease and fractures. The anticonvulsant valproate is a hepatic enzyme inhibitor, effective in many types of epilepsy. The present study aimed to assess the impact of long-term valproate monotherapy on BMD in a sample of consecutive ambulatory adult patients with epilepsy.Methods/design: This cross-sectio...