Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1553 | Steroid metabolism + action | ICEECE2012

The role of long-acting parenteral testosterone undecanoate compound (Nebid 1000 mg) in the induction of secondary sexual characteristics (SSC) in males with hypogonadotropic hypogonadism (HH)

Giagulli V. , Triggiani V. , Corona G. , Tafaro E. , Licchelli B. , Guastamacchia E.

Testosterone (T) can induce SSC in young HH men. So far the T ester formulations have been used for inducing puberty in these patients. Moreover, it seems that the polymorphism CAG length of androgen receptor (AR-CAG) might co-regulate the effectiveness of testosterone therapy (Tth).This study aims to evaluate the effectiveness of Nebid (1000 mg) for SSC induction in HH men and, secondly, whether these changes might be modulated by the AR-CAG.<p clas...

ea0029p1049 | Male Reproduction | ICEECE2012

Effectiveness of gonadotropin treatment for spermatogenesis induction in hypogonadotropic hypogonadism: a possible role of androgen receptor CAG repeat polymorphism

Giagulli V. , Triggiani V. , Tafaro E. , Corona G. , Licchelli B. , Resta F. , Sabba' C. , Maggi M. , Guastamacchia E.

Prepuberal-onset HH (PRHH) and postpuberal-onset HH (PSHH) men required GnTh by means of administration of both the β human chorionic gonodadotropin (ηHCG) and the FSH to induce a complete spermatogenesis. However, the response to GnTh is always unpredictable concerning either the effectiveness or the duration of the therapy. Consequently, different studies have been carried out to identify clinical and biochemical markers that can be useful to predict the effectiven...

ea0029p1824 | Thyroid cancer | ICEECE2012

Iodine-131 lung uptake in bronchiectasis: a potential pitfall in the follow up of differentiated thyroid carcinoma (DTC)

Triggiani V. , Giagulli V. , Tafaro E. , Guastamacchia E.

DTC carries a good prognosis when adequately treated by means of total thyroidectomy, iodine-131 (I-131) treatment and TSH-suppressive therapy, and carefully followed up (i.e. serum thyroglobulin, I-131 total). In some cases, however, false-positive scans can occur. A 42-yr-old woman with recurrent chest infections and bronchiectasis was submitted to total thyroidectomy because of a13 mm nodule in the right lobe that showed a papillary thyroid carcinoma at FNAB histological ex...

ea0026p384 | Thyroid (non cancer) | ECE2011

Occurrence and prognostic impact of hypothyroidism in chronic heart failure

Triggiani V , Iacoviello M , Monzani F , Giagulli V A , Tafaro E , Guida P , Guastamacchia E , Favale S

The aim of this study was to define the occurrence of hypothyroidism and its impact on CHF progression. Four hundred and twenty-two consecutive outpatients (326 males, aged 65±12 years) with CHF in stable condition and conventional therapy were evaluated. Thyroid status was checked at least every 4 months. The progression of heart failure was defined as death, urgent heart transplantation, or hospitalisation due to worsening HF.<img src="/ea/0026/ima...

ea0011p802 | Thyroid | ECE2006

Thyroid cancer: diagnostic role of ultrasound and ultrasound-guided fine needle aspiration biopsy (US-FNAB) evaluation

Triggiani V , Guastamacchia E , Resta F , Sabba’ C , Tafaro E

Aim of this study was the evaluation of the accuracy of ultrasound and US-FNAB in the diagnosis of thyroid cancer in a population of subjects submitted to US-FNAB of all thyroid nodules, with no prior selection. 1803 patients (1447 females e 356 males, age range 11 – 87 years, mean 49.6±13.7, with a total of 3378 nodules) were submitted by the same physician (first author) to ultrasound evaluation and US-FNAB of all thyroid nodules. Results. The nodules were 3 to 90 ...

ea0011p803 | Thyroid | ECE2006

Parathyroid hormone determination in fine needle aspirates (PTH-FNAB) allows the differentiation between thyroid and parathyroid lesions

Triggiani V , Guastamacchia E , Resta F , Sabba’ C , Tafaro E

Parathyroid lesions are often occasionally discovered during thyroid ultrasound evaluation (incidentalomas); in other cases there is a previous diagnosis of hyperparathyroidism. In many cases it is difficult or even impossible to distinguish these lesions from those of thyroid origin, because they often share common ultrasound features. Scintiscan and cytology are also frequently inadequate. The aim of this study is to evaluate the contribute of PTH determination in the aspira...

ea0049gp215 | Thyroid 2 | ECE2017

Hypothyroidism and heart failure outcome: a study with a long-term follow-up

Triggiani V , Licchelli B , Rizzo C , Grande D , Terlizzese P , Leopizzi T , Gioia I , Giagulli VA , Guastamacchia E , Iacoviello M

Background: Hypothyroidism (HT) has been demonstrated to be associated to heart failure (HF) progression.Aim of the study: To evaluate the impact of HT on the progression of HF during a long-term follow-up.Methods: From 2006 to 2015, we evaluated 675 consecutive CHF outpatients (523 males, 64±13 years) in stable clinical conditions (>1 month) and in conventional therapy. They underwent a clinical evaluation, 12-lead ECG, e...

ea0049gp216 | Thyroid 2 | ECE2017

The correction of TSH with thyroid replacement therapy is associated with a better outcome in chronic heart failure patients

Triggiani V , Licchelli B , Grande D , Rizzo C , Terlizzese P , Giagulli VA , Lattarulo M.S , Leopizzi T , Gioia I , Guastamacchia E , Iacoviello M

Background: It has been previously demonstrated that thyroid hormone deficiency is associated with a worse outcome in patients affected by chronic heart failure (CHF). However, few data are available about the effects of thyroid replacement therapy on the prognosis of patients.Aim of the study: The aim of the study was to evaluate the relationship among thyroid replacement therapy, correction of thyroid stimulating hormone (TSH) serum levels and outcome ...