Searchable abstracts of presentations at key conferences in endocrinology

ea0022p656 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Diabetes Mellitus influence on GH and IGF-1 levels in acromegalic patients

Alexander Dreval , Irina Trigolosova

Background: Diabetes mellitus is one of the serious acromegaly complication.As well known, glycemia influences growth hormone (GH) secretion. From this point of view, it is interesting to investigate feature peculiarity of GH and Insulin like Growth Factor 1 (IFG-1) secretion when acromegaly is coupled with diabetes mellitus.Aim: Of this study was to investigate diabetes mellitus influence on GH and IGF-1 levels in acromegalic pati...

ea0041ep927 | Pituitary - Clinical | ECE2016

Results of transsphenoidal surgery and somatostatin analogues therapies and their combination in acromegaly

Trigolosova Irina , Dreval Alexander , Panteleeva Evgenia , Molchanova Galina , Chikh Irina

Introduction: Data on transsphenoidal surgery (TSS) and effect of somatostatin analog therapy (SSA) in acromegaly different among medical centers. We analyzed the data on TSS, SSA and their combination in acromegalic patients of Moscow region.Design: In this study 117 acromegalic patients (25 males and 92 females, 55.0 (IQR 44 – 62) years) were eligible for participation, of whom 34 were newly-diagnosed aromegaly (NA group) (macroadenoma (macro)- 80...

ea0037ep383 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

Mechanisms of development of carbohydrate metabolism disturbances in acromegalic patients depending on treatment

Dreval Alexander V , Trigolosova Irina V , Vinogradova Anna V , Wolffenbuttel Bruce H R

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. The effect of therapy of acromegaly on pathogenesis of CMD is not clear.Aim: To assess the effect of somatostatin analogues (SSA) on pathogenesis of carbohydrate metabolism disturbance in acromegaly.Patients and methods: 103 acromegaly patients were examined (31 men, 72 women; age 54 (46–61) years; 60 had newly diagnosed acromegaly (NA)...

ea0035p373 | Diabetes (epidemiology, pathophysiology) | ECE2014

Acromegaly treatment and carbohydrate metabolism disturbances

Dreval Alexander V. , Trigolosova Irina V. , Vinogradova Anna V. , Ilovayskaya Irena A. , Wolffenbuttel Bruce H.R.

Background: In acromegaly, carbohydrate metabolism disorders (CMD) are frequently observed. We aimed to assess the differences in insulin secretion and sensitivity depending on stage of the disease and type of treatment.Design: Sixty-four patients with acromegaly (46 women; age 53 (interquartile range, IQR 47–59) years), of whom 29 were newly-diagnosed (NA group), 20 treated with somatostatin analogues (SSA group) and 15 after transsphenoïdal s...

ea0041ep403 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Prevalence of diabetes mellitus in patients with hypercortisolism

Dreval Alexander , Trigolosova Irina , Kruglyakova Margarita , Komerdus Irina , Misnikova Inna , Kovaleva Yulia , Chekanova Anastasia , Barsukov Ilya , Molchanova Galina , Wolffenbuttel Bruce

Background: Early carbohydrate metabolism disorders (ECMDs) and diabetes mellitus (DM) are frequently associated with endogenous hypercortisolism (EG). Prevalence of secondary (sDM) in these cases are poorly investigated.Aim: We aimed to assess the prevalence of ECMDs and DM in patients with EG (pituitary-dependent Cushing disease (CD)) and adrenal-dependent Cushing (AC) and ACTH-ectopic syndrome (ACTHs) depending on gender and age.<p class="abstext"...