Searchable abstracts of presentations at key conferences in endocrinology

ea0029mte25 | (1) | ICEECE2012

Pituitary incidentalomas

Tsagarakis S.

During the past several years the wide application of sensitive brain imaging techniques (CT, MRI) has led to an increasing recognition of asymptomatic lesions in the pituitary. Although their etiology covers a wide range of pathologies, most incidentally discovered pituitary lesions are benign adenomas, ranging in size from micro- (<10 mm) to macro- (>10 mm) adenomas. Micro-incidentalomas are very common, with a reported incidence in normal individuals of 4–20%. ...

ea0083cbo4 | Calcium and Bone | EYES2022

Markers of cardiometabolic and bone health in postmenopausal women on glucocorticoid replacement therapy due to adrenal insufficiency

E Kardalas , D. A. Vassiliadi , A Angelousi , V Lambadiari , S Tsagarakis

Background: Individuals with adrenal insufficiency (AI) receive life-long glucocorticoid (GC) replacement which often exceeds physiological daily GC production, with negative effects on cardiometabolic and bone health parameters.Objective: Assessment of cardiometabolic and bone health markers in postmenopausal females with AI in relation to the GC dose.Methods: We retrospectively collected 114 postmenopausal women with AI (37 with ...

ea0037ep79 | Adrenal cortex | ECE2015

Functional muscle capacity and daily physical activity deficits in patients with endogenous Cushing's syndrome

Assimakopoulou A , Louvaris Z , Balomenaki M , Chynkiamis N , Tzanela M , Vogiatzis I , Tsagarakis S

Cushing’s syndrome (CS) is a disease entity that through hypercortisolism affects all body’s tissues leading to increased morbidity, decreased quality of life and mortality. Muscles are among the tissues primarily affected. However, data on the impact of endogenous hypercortisolism on functional muscle capacity and daily physical activity levels are scarce. We studied 23 subjects with endogenous CS (mean age: 40.73±2.17 years) and 22 healthy aged and sex matched...

ea0032p28 | Adrenal cortex | ECE2013

The role of late-night salivary cortisol measurement in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentalomas

Perogamvros I , Tzanela M , Koletti A , Tsirona S , Memi E , Tsagarakis S

The diagnosis of subclinical hypercortisolism (SH) is a challenging issue, especially as the high prevalence of adrenal incidentalomas (AI) is increasingly recognized. The diagnosis of subclinical hypercortisolism relies on a combination of tests that include overnight (ODST) or low dose dexamethasone suppression (LDDST), plasma ACTH, and 24-h urinary free cortisol (UFC). Late night salivary cortisol (LNSC) has been successfully used in the diagnosis of Cushing’s syndrome...

ea0029p72 | Adrenal cortex | ICEECE2012

ACTH and cortisol responses to the combined DEXA-CRH test in patients with adrenal incidentalomas

Tzanela M. , Tsatlidis V. , Margelou E. , Tampourlou , Mazarakis N. , Piaditis G. , Tsagarakis S.

Adrenal incidentalomas (AI) are a common finding in patients studied by abdominal imaging and approximately 9–17% is found bilaterally. So far, the potential role of hypothalomo-pituitary adrenal (HPA) axis dysregulation in the pathogenesis of AI, especially of those found bilaterally, has not been addressed. The DEXA-CRH test has been previously used to detect dysregulation of the HPA axis; herein, it was used to assess ACTH and cortisol responses in a large group of pat...

ea0029p1513 | Pituitary Clinical | ICEECE2012

Therapeutic trends, long-term outcome and efficacy of different treatment modalities in acromegaly: a single center registry covering a 40 year period

Tzanela M. , Karapanou O. , Assimakopoulou A. , Papastathopoulou L. , Christophoraki M. , Tsagarakis S.

The aim of the study was to examine the therapeutic trends and the long-term outcome of available therapeutic modalities for acromegaly in a single center over a 40 year period.We retrospectively studied 300 acromegalic patients (131 men, 169 women, 153 macroadenomas and 147 microadenomas) from 1970 until 2010; 154 patients were diagnosed before 1990 (group A) and 146 after 1990 (group B). Outcome was evaluated by IGF1 and GH (random plus post OGTT) meas...

ea0014p125 | (1) | ECE2007

A newly detected mutation of the RET proto-oncogene in exon 8 as a cause of multiple endocrine neoplasia Type 2A

Bethanis S. , Palouka Th. , Avgoustis Ch. , Koutsodontis G. , Bei T. , Yannoukakos D. , Tsagarakis S.

Multiple endocrine neoplasia type2A (MEN 2A) is a syndrome of familial cancers characterized by medullary thyroid carcinoma (MTC), pheochromocytoma and hyperplasia of the parathyroid glands. RET protooncogene is the responsible gene for MEN 2A; in more than 96% of MEN 2A families mutations in RET exon 10 or exon 11 are identified. Herein we report a MEN 2A case affected by a mutation (Gly533Cys) in exon 8. A 66-yr-old male patient was referred to our Department due ...

ea0011oc20 | Clinical endocrinology | ECE2006

A European prospective real-life observational study of Quality of Life in patients with acromegaly

Webb SM , Colao A , Caron P , Carvalheiro M , Ertürk E , Pokrajac-Simeunovic A , Schopohl J , Tsagarakis S , Pearson IV , Badia X , Caglio S , Vincenzi B

The primary aim of this study, the largest European, single evaluation, observational trial to date, was to evaluate the impact of acromegaly on health-related quality of life (HRQoL) in patients with biochemically documented active disease, receiving Sandostatin® LAR® at a dose prescribed by their physician for at least 3 months. Secondary objectives were to investigate the relationships between HRQoL and subpopulations based on exploratory var...