Endocrine Abstracts

Background: The third generation thyrotropin receptor antibodies (TRAb) assay has high sensitivity and specificity in diagnosing Graves’ disease (GD). Circulating levels of TRAbs predict the disease course of Graves’ orbitopathy (GO) and remission rates in GD. However, the relationship between TRAb and thyroxine (FT4) and the factors affecting their interaction are unclear.Method: A prospective cohort study was conducted to evalua...

Background: The third generation thyrotropin receptor antibodies (TRAb) assay has high sensitivity and specificity in diagnosing Graves’ disease (GD). Circulating levels of TRAbs predict the disease course of Graves’ orbitopathy (GO) and remission rates in GD. However, the relationship between TRAb and thyroxine (FT4) and the factors affecting their interaction are unclear.Method: A prospective cohort study was conducted to evalua...

Background: There is little information regarding the natural history of subclinical hyperthyroidism (SH) due to Graves’ disease (GD). The objectives of this study were to assess the natural course of individuals with SH due to GD over a prolonged period. We also investigated the factors contributing to the progression or remission in these patients.Methods: A prospective analysis of patients with SH due to GD between 2007 and 2013 who had at least ...

Introduction: Copeptin is the C-terminal fragment of proAVP and provides an alternative measure of AVP secretion. While direct measurement of AVP during hypertonic saline infusion has been recommended as a diagnostic test for diabetes insipidus (DI), the number of reports examining the utility of copeptin in this context is limited. Here we describe a series of cases where measurement of copeptin during saline infusion has contributed to ...

Introduction: Copeptin is the C-terminal fragment of proAVP and provides an alternative measure of AVP secretion. While direct measurement of AVP during hypertonic saline infusion has been recommended as a diagnostic test for diabetes insipidus (DI), the number of reports examining the utility of copeptin in this context is limited. Here we describe a series of cases where measurement of copeptin during saline infusion has contributed to ...

Aberrant adrenal LH expression is a rare cause of adrenal Cushing’s syndrome (CS) leading to transient hypercortisolism during pregnancies and ACTH-independent macronodular adrenal hyperplasia (AIMAH) after the sustained postmenopausal increase of LH secretion. Subclinical CS due to aberrant LH expression has very rarely been described. Herein, we report a case with aberrant LH/hCG adrenal receptor mediated subclinical CS in a patient with incidentally discovered AIMAH an...