Searchable abstracts of presentations at key conferences in endocrinology

ea0032p739 | Obesity | ECE2013

Corticotrophin realising factor affects the immune phenotype of adipocytes via CRF1 and CRF2 receptors

Dermitzaki Eirini , Liapakis George , Androulidaki Ariadni , Tsatsanis Christos , Margioris Andrew

Introduction: The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors affect innate immunity. A fully working peripheral CRF system is present in adipose tissue. In obesity, macrophages and adipocytes interact causing local and systemic inflammation. In addition, macrophages and adipocytes share common characteristics including production of inflammatory cytokines in response to lipopolysaccharides (LPS) via the toll-like receptor-4 (TLR4) which b...

ea0032p781 | Obesity | ECE2013

Circulating adiponectin as marker of obesity-induced chronic low grade inflammation

Dermitzaki Eirine , Avgoustinaki Pavlina , Venihaki Maria , Tsatsanis Christos , Margioris Andrew

Introduction: Obesity lowers adiponectin levels. Adiponectin has anti-inflammatory effects. It has been suggested that the lower levels of adiponectin in obesity results in chronic low grade inflammation (CLGI). Aim of this study was to examine if plasma adiponectin is a valid marker of CLGI in normal weight, overweight and obese individuals. In addition, we also assessed adiponectin as marker of body fat and insulin resistanceMethods: We measured adipon...

ea0014p272 | (1) | ECE2007

CRF and the Urocortins activate NFAT and induce catecholamine production in PC12 cells

Dermitzaki Erini , Tsatsanis Christos , Androulidaki Ariadne , Venihaki Maria , Gravanis Achille , Margioris Andrew

We have previously shown that Corticotropin – releasing factor (CRF) and Urocortins (UCNs) induce the production of catecholamines from normal human and rat adrenal chromaffin and PC12 pheochomocytoma cells via induction of tyrosine hydroxylase, the rate limiting enzyme of catecholamine biosynthesis. We have also shown that CRF induces calcium ion entrance into the cytoplasm from both extracellular sources (influx) and from intracellular stores (mobilization) in PC12 cell...