Endocrine Abstracts

Introduction: Anti-epileptic drugs, usually defined according to their effect on the cytochrome P450 system, might lead to bone mineral density (BMD) decrease and fractures. The anticonvulsant valproate is a hepatic enzyme inhibitor, effective in many types of epilepsy. The present study aimed to assess the impact of long-term valproate monotherapy on BMD in a sample of consecutive ambulatory adult patients with epilepsy.Methods/design: This cross-sectio...