Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep780 | Obesity | ECE2016

Glucose and insulin up-regulate the cardiovascular biomarker GDF15 in vivo and in vitro: effect of meal content and obesity

Schernthaner-Reiter Marie Helene , Kasses Dominik , Tugendsam Christina , Riedl Michaela , Peric Slobodan , Clodi Martin , Luger Anton , Vila Greisa

Introduction: Growth differentiation factor 15 (GDF15) has recently been characterized as a cardiovascular risk factor. GDF15 correlates with insulin resistance and obesity in cross-sectional studies and exerts anorexigenic effects in interventional rodent studies. GDF15 has been proposed as a possible therapeutic target in the treatment of obesity, however its meal- and nutrient-dependent regulation in humans has not been investigated previously.Methods...