Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp198 | Thyroid - Basic | ECE2016

Differences in gene–gene interactions in Graves’ disease patients stratified by the age of diagnosis

Jurecka-Lubieniecka Beata , Bednarczuk Tomasz , Ploski Rafal , Kula Dorota , Tukiendorf Andrzej , Kolosza Zofia , Jarzab Barbara

Background: The genetic predisposition of Graves’ disease (GD) was proved by the identification of genes with substantial, non-interactive effects on the disease process. It is known, however, that genetic interactions significantly increase the likelihood of immune-tolerance-related complex diseases like allergic asthma and rheumatoid arthritis. In the present study we analyzed the effects of interactions of multiple loci on the genetic predisposition to GD patients....

ea0049ep349 | Endocrine tumours and neoplasia | ECE2017

Parathyroid cancer – clinical presentation, prognostic factors and long-term evolution

Jurecka-Lubieniecka Beata , Michalik Barbara , Bula Grzegorz , Gawrychowski Jacek , Kajdaniuk Dariusz , Marek Bogdan , Tukiendorf Andrzej , Jarzab Barbara

Background: Parathyroid carcinoma (PC) is a rare endocrine malignancy affecting 0.5–5% of all patients with primary hyperparathyroidism. Due to the rarity of PC there is still lack of prognostic implications of the disease and clear consensus regarding management. Our purpose was to evaluate prognostic factors and treatment outcomes of patients treated at the Department of Nuclear Medicine and Endocrine Oncology.Methods: The target group covered 44 ...

ea0035p1015 | Thyroid (non-cancer) | ECE2014

Differences in genetic predisposition to Graves' disease and Graves' orbitopathy between young and elderly patients

Jurecka-Lubieniecka Beata , Ploski Rafal , Kula Dorota , Stechly Tomasz , Krol Aleksandra , Bednarczuk Tomasz , Tukiendorf Andrzej , Kolosza Zofia , Jarzab Barbara

Background: Graves’ disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. The pathogenesis of GD and Graves’ orbitopathy (GO) might have a different genetic background – in some patients GO is observed before or late after diagnosis of GD hyperthyroidism. The aim of the study was to assess genetic predisposition to GD and GO in young patients (age of diagnosis ≤30 years of age), in which the time of environ...