ea0035oc6.2 | Bone, calcium & vitamin D | ECE2014
Faienza Maria Felicia
, Tummolo Albina
, Piacente Laura
, Fiaschetto Rita
, Ciccarelli Maria
, Ventura Annamaria
, Papadia Francesco
, Colucci Silvia
, Grano Maria
, Cavallo Luciano
, Brunetti Giacomina
Background: Osteogenesis imperfecta (OI) is a heritable disease of the connective tissues caused primarily by heterogeneous mutations in the genes encoding for type I collagen. Phenotypically, it is characterized by abnormal bone mineralization, tissue fragility, and skeletal deformities.Objective: The aim of this study was to investigate the osteoclastogenic potential of unfractionated peripheral blood mononuclear cells (PBMCs) from OI patients (mean ag...