Searchable abstracts of presentations at key conferences in endocrinology

ea0011s38 | Stromal cell-matrix interactions | ECE2006

Role of heparan sulphates in neuronal stem cell differentiation

Turnbull JE , Hemers E , Limaye P , Burrell H , Drummond K , Wells N , Yates EA , Murray P

Heparan sulphate (HS) is a highly complex linear polysaccharide found attached to core proteins both on the cell surface and in the extracellular matrix. Newly synthesized HS chains are modified by a family of enzymes, many of which have multiple isoforms with differing substrate preferences. These modifications include the addition of sulphate groups at up to four positions on each disaccharide unit. The pattern of modifications a HS saccharide undergoes alters its structure,...