Endocrine Abstracts

Introduction: Primary hyperparathyroidism (pHPT) is the most frequent cause of hypercalcemia in ambulatory patients. Most persons have no symptoms, and pHPT usually is diagnosed after an elevated serum calcium (Ca2+) level is found incidentally. Parathyroidectomy is the definitive treatment for pHPT. There have been several different approaches to the medical management of pHPT. Our aim in this study is to compare alendronate sodium (ALN) and raloxifene (RLX) effici...

Objective: Patients with hyperprolactinemia who require medical therapy are typically treated with dopamine agonists (DA). In most cases, medical therapy with DA normalizes the level of prolactin (PRL), restores gonadal function and fertility, and substantially reduces the size of the tumor. Here, we aimed to compare the efficacy of cabergoline (CAB) and bromocriptine (BRC) in hyperprolactinemic patients retrospectively.Methods: Retrospective analysis of...

Objective: Long acting somatostatin analogs commonly used as adjuvant treatment of acromegalic patients after noncurative surgery. We aimed to compare the efficacy of octreotide LAR (OCT) and lanreotide Autogel (LAN) in acromegalic patients.Methods: Sixty-eight patients that cure could not be achieved by transsfenoidal endoscopic or microscopic pituitary surgery between 2003 and 2009 were retrospectively analyzed (25 men and 43 women; mean age 41.1±...

Objective: Most of the papillary thyroid microcarcinomas (PTMC) are incidentally discovered in pathological examination after the surgery of benign thyroid disorders. The purpose of the present study was to evaluate clinicopathologic features of incidental and nonincidental PTMC.Material and methods: We evaluated 56 patients with PTMC between 2003 and 2008 at the Division of Endocrinology of the Numune Training and Research Hospital. We analyzed the tumo...

Objective: We designed this study to evaluate whether visceral fat area (VFA), and subcutaneous fat area (SFA) are associated with atherosclerotic parameters in obese and non-obese subjects.Material and methods: Of 104 healthy volunteers were recruited for the study. Participitants were divided into two groups according to their body mass index (BMI). Group 1 has a BMI of <25 kg/m2 (n=31) and the BMI of the group 2 was ≥25 kg/...

Objective: Acromegaly is associated with an increased prevalence of colonic polyps. The aim of this study was to evaluate the prevalence of colonic polyps in acromegalic subjects, and also whether there is a relationship between insulin-like growth factor 1 (IGF-1), growth hormon (GH), fasting insulin plasma levels and the presence of polyps.Material and methods: Fifty-four consecutive acromegalic patients and 45 IBS patients were enrolled to study betwe...

In this study we compared plasma adiponectin levels between patients with non-functional adrenal incidentaloma and subclinical Cushing’s syndrome. Our aims were to determine whether there was any difference of plasma adiponectin levels, any relation between cardiovasculer risk factors and to investigate the importance of adiponectin levels in subclinical Cushing’s syndrome patients according to non-functional adrenal incidentaloma patients. The patients referred from...

Objective: Our aim was to determine the prevalence and clinicopathological characteristics of thyroid cancers in the dialysis population and to evaluate potential risk factors.Design: We performed a retrospective analysis of our end-stage renal disease (ESRD) patients on dialysis and thyroidectomized patients without ESRD (2000–2006). Then we compared the data of thyroid cancer patients on dialysis (n=9) with the data of patients who had hist...

Objective: The thiazolidinediones are new and potentially useful developments in the treatment of type 2 diabetes and impaired glucose tolerance. We tested the effects of the thiazolidinedione, rosiglitazone on blood pressure in normotensive type 2 diabetes.Methods: After receiving approval from the local ethics committee, 25 normotensive diabetic patients were were enrolled to the study. Before the rosiglitazone treatment we measured plasma glucose, HbA...

Purpose: Adrenal incidentalomas (AIs) are adrenal masses, which are found on imaging studies not performed related to an adrenal problem. Hepatic incidental masses and renal incidental masses are usually seen in abdominal imaging methods. We aim to investigate the frequency and the kind of hepatic and renal incidental masses in patients with AIs.Methods: Retrospective evaluation of 381 (245 female and 136 male) AI patients and 285 (168 female and 117 mal...