Searchable abstracts of presentations at key conferences in endocrinology

ea0038p325 | Pituitary | SFEBES2015

Using modified clamp study to replicate insulin stress test

Tan Horng Kai , Twine Gina , Flanagan Daniel

Introduction: Insulin stress test (IST) has long been the gold standard for testing the hypothalamus-pituitary–adrenal (HPA) axis. There are concerns about the safety of IST as hypoglycaemia can give rise to various symptoms including seizure and coma although this is rarely seen in clinical practice. Hyperinsulinaemic hypoglycaemic clamp is a common research procedure used to induce hypoglycaemia in a step-wise fashion to study the effect of hypoglycaemia.<p class="a...

ea0013p279 | Steroids | SFEBES2007

Comparison of 24 hour urine free cortisol measurement and hydrocortisone day curve in the assessment of hydrocortisone replacement in hypoadrenal patients

George Ajith , Twine Gina , Flanagan Daniel

Hydrocortisone day curves, Salivary cortisols, timed urinary free cortisols and 24 hour urine cortisols have been used to estimate hydrocortisone replacement in hypoadrenal patients.We looked at 39 patients who had hydrocortisone day curve estimations in our hospital. 35 of those patients had simultaneous 24 hour urine free cortisol estimation. All hypothyroid patients were on adequate replacement dose of thyroxine.The commonest cl...

ea0065p299 | Neuroendocrinology | SFEBES2019

Use of serial Short Synacthen tests (SST) in determining failure of hypothalamic–pituitary−adrenal (HPA) axis in patients with pituitary disorders

Koutroukas Vaios , Twine Gina , Flanagan Daniel , Aziz Aftab

Introduction: The study aim was to compare serial Short Synacthen test (SST) results to diagnose secondary Adrenal Insufficiency (AI) in patients with confirmed pituitary diseases.Methods: Serial SST results of patients, tested between 2006 and 2018 in the department of Diabetes and Endocrinology, at a tertiary centre, were reviewed retrospectively. Patient details were obtained from local dynamic test database, maintained by Endocrine Nurse Specialist. ...

ea0021p109 | Clinical practice/governance and case reports | SFEBES2009

Primary medical therapy of acromegaly

Flanagan Daniel , Twine Gina , Pobereskin Lou , Adams William

The current paradigm for management of acromegaly includes surgery as primary treatment regardless of whether or not this is likely to be curative. There is increasing evidence that somatostatin analogue medical therapy may produce shrinkage of growth hormone producing pituitary tumours. This study tests the hypothesis that primary medical therapy may produce clinically significant tumour shrinkage prior to surgery.Eleven treatment naïve subjects wi...

ea0013p207 | AMEND Young Investigator's Award | SFEBES2007

The effect of lanreotide autogel on insulin resistance, β-cell function and related metabolic variables in acromegaly

Franke Bernd , Twine Gina , Flanagan Daniel , Wilkin Terry

Background: Growth hormone (GH) excess is associated with increased insulin resistance (IR). Lanreotide autogel (Autogel) reduces GH-levels effectively in patients with active acromegaly. However, the effect of somatatostatin analogues on IR and (-cell function (HOMA %B) is complex and unpredictable. Our study prospectively monitored IR and related metabolic parameters in acromegalics treated with Autogel.Methods: Nine patients (P) with active acromegaly...

ea0065p306 | Neuroendocrinology | SFEBES2019

Long term effects of cranial radiotherapy on hypothalamic–pituitary–adrenal axis in patients with established pituitary diseases

Koutroukas Vaios , Bond Hannah , Lim Elizabeth , Twine Gina , Flanagan Daniel , Aziz Aftab

Introduction: Radiotherapy is an important adjuvant treatment for pituitary and cranial diseases. The aim of the study was to observe response of Radiotherapy (RTX) on Hypothalamic–Pituitary–Adrenal (HPA) axis determined by serial Short Synacthen tests (SSTs). Methods: Patients treated with adjuvant Cranial Radiotherapy between the years 2000 and 2018 in the department of Radiation Oncology and who also underwent serial Short Synacthen tests, i...