Searchable abstracts of presentations at key conferences in endocrinology

ea0063p416 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

High prevalence of autonomous aldosterone secretion in patients with type 2 Diabetes Mellitus and arterial hypertension. The effect of SGLT2 inhibitors on renin-angiotensin-aldosterone system

Tyfoxylou Ernestini , Papanastasiou Labrini , Piaditis George , Voulgaris Nikolaos , Chrousos George , Kounadi Theodora

Introduction: The causes of arterial hypertension in diabetic and non-diabetic hypertensive patients are still not clear. However, in recent studies in non-diabetic hypertensive patients (NDHP) we observed dysregulation of aldosterone (ALD) secretion either in the form of autonomous secretion or as hyperesponse to stress. To the best of our knowledge, a similar study in hypertensive patients with type 2 Diabetes Mellitus (DHP) has not been conducted yet....

ea0070aep67 | Adrenal and Cardiovascular Endocrinology | ECE2020

Hyperparathyroidism in patients with overt and mild primary aldosteronism: Epidemiological data from a tertiary centre

Gravvanis Christos , Papanastasiou Labrini , Glikofridi Spyridoula , Voulgaris Nikolaos , Tyfoxylou Ernestini , Kounadi Theodora

Introduction: Primary aldosteronism (PA) is the most common cause of endocrine hypertension. In recent studies, increased prevalence of hyperparathyroidism (HP) has been observed in PA patients. However, the prevalence of HP in overt or milder forms of PA has not been evaluated yet.Objectives: To estimate the prevalence of HP in patients with PA (overt and milder forms) and investigate the effect of treatment (eplerenone or surgery) on PTH secretion....

ea0070aep63 | Adrenal and Cardiovascular Endocrinology | ECE2020

Surgical outcomes of adrenalectomy for primary hyperaldosteronism after using novel diagnostic tests

Alexandraki Krystallenia , Markou Athina , Papanastasiou Labrini , Tyfoxylou Ernestini , Kapsali Chara , Gravvanis Christos , Kaltsas Gregory , Zografos Giorgos , Piaditis George

Background: Primary hyperaldosteronism (PHA) is the most frequent type of endocrine hypertension with a prevalence that is continuously rising. Following the introduction of diagnostic tests that consider both the adrenocorticotropic hormone effect andrenin–angiotensin–aldosterone system (RAAS), the post-dexamethasone saline infusion test (D-SIT) and the overnight dexamethasone, captopril, valsartan test (DCVT) using pharmaceutical RAAS blockade, a higher prevalenc...

ea0056p92 | Clinical case reports - Pituitary/Adrenal | ECE2018

Severe pheochromocytoma crisis, Type B, resulting in Takotsubo-like cardiomyopathy and fulminant refractory cardiogenic shock, successfully treated with extracorporeal membrane oxygenation (ECMO) but with fatal neurological sequelae for the patient.

Tyfoxylou Ernestini , Kounadi Theodora , Markou Athina , Papanastasiou Labrini , Charalampidou Liana , Kyriazi Evangelia , Voulgaris Nikolaos , Neoklis Skampas , Pyrgakis Vlassios , Piaditis George

Introduction: Catecholamine excess causes profound vasoconstriction, resulting in reduced intravascular volume. Pheochromocytoma crisis can be further complicated with acute stress (Takotsubo-like) cardiomyopathy, attributed to the toxic catecholamine effect on the myocardium, and cardiogenic shock leading to tissue ischemia.Aim: To present a rare case of pheochromocytoma crisis, complicated with fulminant cardiogenic shock, which led to life-threatening...

ea0073oc1.4 | Oral Communications 1: Adrenal and Cardiovascular Endocrinology | ECE2021

The impact of targeted treatment on echocardiographic indices in patients with overt and mild primary aldosteronism, compared to patients with essential hypertension.

Gravvanis Christos , Papanastasiou Labrini , Kaoukis Andreas , Glikofridi Spyridoula , Monastirioti Nicoleta , Voulgaris Nikolaos , Ernestini Tyfoxylou , Markou Athina , GeorgePiaditis

IntroductionPrimary aldosteronism (PA) is associated with cardiovascular events and target organ damage, such as left ventricular (LV) hypertrophy and cardiac dysfunction. However the impact of subtle aldosterone secretion on cardiac function has not yet been evaluated.AimTo prospectively evaluate the cardiac function using echocardiographic indices in patients with biochemical overt, mild PA and essential hy...

ea0056p20 | Adrenal cortex (to include Cushing's) | ECE2018

Prevalance of primary aldosteronism in hypertensive patients: epidemiological data from a tertiary centre

Voulgaris Nikolaos , Papanastasiou Labrini , Vlachou Sofia , Kyriazi Evangelia , Tyfoxylou Ernestini , Monastirioti Nikoletta , Kapsali Chara , Charalampidou Liana , Aglaia Zachaki , Kalantzi Athanasia , Gravvanis Christos , Markou Athina , Giagourta Eirini , Kounadi Theodora , Kassi Eva , Kaltsas Gregory , Piaditis George

Introduction: Primary aldosteronism (PA) is the most common cause of endocrine hypertension. Its prevalence varies from 5-15%, which depends mainly on the cut-offs of the diagnostic tests.Aim: To estimate the prevalence of PA in patients with different stages of hypertension based on a dynamic overnight diagnostic test.Methods: One hundred ninety nine hypertensive patients were divided in 3 groups according to the stage of hyperten...

ea0056p21 | Adrenal cortex (to include Cushing's) | ECE2018

Renin: a possible novel marker for the efficacy of pharmacological treatment of primary aldosteronism

Voulgaris Nikolaos , Vlachou Sofia , Kyriazi Evangelia , Papaoikonomou Eleni , Tyfoxylou Ernestini , Monastirioti Nikoletta , Kapsali Chara , Zachaki Aglaia , Charalampidou Liana , Kounadi Theodora , Markou Athina , Papanastasiou Labrini , Giagourta Eirini , Kassi Eva , Kaltsas Gregory , Piaditis George

Introduction: Primary aldosteronism (PA) treatment is either pharmacological with aldosterone receptor antagonists (MRAs) or surgical with the resection of the responsible adenoma. The efficacy of MRAs treatment is based on the normalization of blood pressure (BP) in relation to potassium levels. However, it remains unclear whether the stimulation of renin levels during treatment could serve as an additional marker of adequate MR blockade.Aim: To investi...

ea0099p418 | Adrenal and Cardiovascular Endocrinology | ECE2024

Appraisal of modified tests for the diagnosis and treatment of primary aldosteronism: A single endocrine center experience

Markou Athina , Kaltsas Gregory , Papanastasiou Labrini , Voulgaris Nikolaos , Gouli Aggeliki , Tsiavos Vaios , Gravvanis Christos , Tyfoxylou Ernestini , Vlachou Sofia , Kapsali Chara , Giagourta Irini , Kounadi Theodora , Vamvakidis Kyriakos , Zografos George , Chrousos George , Piaditis George

Introduction: Primary aldosteronism (PA), the most common endocrine cause of secondary hypertension, is generally underdiagnosed using current diagnostic tests.Aim: To present our 14-year experience of prospective studies on the diagnosis, prevalence and treatment of PA.Patients and methods: We studied 992 hypertensive patients and 278 age-, sex- and body mass index – matched controls (194 normotensive and 104 with essential h...