Endocrine Abstracts

Introduction: Acromegaly is associated with skeletal changes that are characterized by appositional bone growth, increased bone dimensions and increased bone turnover. PTH is an important regulator of bone remodeling and its anabolic action requires the presence of GH. The strong correlation found between PTH concentrations and bone turnover markers in active and treated acromegaly has led to the suggestion, that the effect of GH on bone turnover may be mediated by PTH. Succes...

Introduction: Thyrotoxicosis has been shown to cause deterioration of glucose levels in patients with DM 2 while return to euthyroidism results in better glycaemic control. Studies in normal subjects suggest that increased thyroid hormones may aggravate insulin resistance and decrease pancreatic secretion of insulin but the exact underlying mechanisms have not been completely elucidated. The purpose of this study was to investigate if this also occurs in subclinical hyperthyro...

Introduction: Recently, several cytokines attracted considerable attention as potential effectors of insulin resistance and endothelium dysfunction, both associated with type 2 diabetes mellitus (T2DM) pathophysiology.Serum lipids disturbances also observed in inflammation and immunologic disorders have been found to largely depend on proinflammatory cytokines release.Aim: To establish the presence of cytokines levels disturbances ...

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually considered low-risk tumors with favorable prognosis. However, a small percentage behaves aggressively and controversies exist for various prognostic factors. The aim of this study was to evaluate demographic and tumor specific characteristics related to PTMC invasiveness.Patients – methods: This is a retrospective study of 510 thyroidectomized patients with PTMC who were treated in t...