Searchable abstracts of presentations at key conferences in endocrinology

ea0032p829 | Pituitary–Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

mTOR mediated IGF1 proliferative effects on a rat pituitary GH/PRL secreting pituitary adenoma cell line

Bellio Mariaenrica , Mirabassi Cecilia , Gagliano Teresa , Uberti Ettoredegli , Chiara Zatelli Maria

IGF1 represents an important growth factor in pituitary physiology and pathology, also mediating the negative feed-back mechanisms on somatotroph axis. It has been previously demonstrated that IGF1 promotes cell viability in primary cultures of human non functioning pituitary adenomas, by a mechanisms involving, at least in part, mTOR signaling, which is involved in many pathways controlling proliferation. We aimed at investigating whether mTOR may mediate IGF1 effects also in...

ea0035oc10.2 | Endocrine Tumours | ECE2014

The cytotoxic effect of sunitinib on human bronchial carcinoid cell lines and primary cultures is counteracted by EGF and IGF-1 but not by VEGF

Gagliano Teresa , Gennari Giulia , Tassinari Martina , Bellio Mariaenrica , Gentilin Erica , Benfini Katiuscia , Uberti Ettoredegli , Zatelli Maria Chiara

Background: Bronchial carcinoids (BC) are rare tumors originating from endocrine cells dispersed in the respiratory epithelium. The main BC treatment is surgery, which is not feasible for large, infiltrating and metastatic disease. In these settings, medical therapy is often tried. Therefore it is important to identify new therapeutic targets and new molecules capable of providing adequate medical treatment for patients with BC. Sunitinib, is an oral, small-molecule, multi-tar...