Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1414 | Thyroid (non-cancer) | ECE2017

Significant difference between the prevalence of C cell hyperplasia (CCH) in benign thyroid nodules without histological thyroiditis (HT) and in papillary/follicular thyroid cancers (PTC/FTC) at histology

Pieruzzi Letizia , Molinaro Eleonora , Agate Laura , Bottici Valeria , Torregrossa Liborio , Ugolini Clara , Basolo Fulvio , Vitti Paolo , Elisei Rossella

Background: CCH and serum hypercalcitoninemia (iperCT) can be found in benign thyroid diseases such as thyroiditis and in some cases of papillary (PTC) or follicular (FTC) thyroid microcarcinomas. The question of whether the association with these latter is related to the malignancy of the nodule is still unclear.Aim of the study: To evaluate the difference in the CCH prevalence, at histology, in a series of benign (BTN) and malignant (PTC/FTC) thyroid n...

ea0040p1 | (1) | ESEBEC2016

Genetic heterogeneity of medullary thyroid carcinoma

Romei Cristina , Ciampi Raffaele , Tacito Alessia , Casella Francesca , Ugolini Clara , Porta Mireira , Torregrossa Liborio , Basolo Fulvio , Elisei Rossella

Genetic intratumor heterogeneity has been recently demonstrated in some solid human cancers and a few years ago RET mutated and not mutated cells were described in medullary thyroid carcinoma (MTC). Nobody reported the presence of two different RET mutations.Aim of our study was to investigate the RET somatic mutation profile in primary MTC (pMTC) and in the corresponding metastatic tissues (mets).We studied pMTC and mets of 22 MTC...

ea0014p362 | (1) | ECE2007

Prognostic value of polymorphisms and somatic RET proto-oncogene mutations in sporadic medullary thyroid carcinoma (MTC)

Cosci Barbara , Romei Cristina , Piampiani Pamela , Sculli Mariangela , Miccoli Paolo , Ugolini Clara , Minuto Michele , Pinchera Aldo , Elisei Rossella

Germline point mutations of the RET proto-oncogene are causative of hereditary MTC. Somatic mutations are described in 40% of sporadic MTCs. Although a relationship between somatic mutations and bad prognosis has been described, data are controversial.No date on the prognostic value of RET polymorphisms are available.Aim of the work was to verify if the presence of a somatic RET mutation and or a polymorphisms can influence the prognosis of MTC. This stu...

ea0014p366 | (1) | ECE2007

Prognostic significance of BRAF mutation in patients affected by papillary thyroid carcinoma with a follow up of 20 years

Viola David , Romei Cristina , Biagini Agnese , Agate Laura , Molinaro Eleonora , Ciampi Raffaele , Renzini Giulia , Giannini Riccardo , Ugolini Clara , Berti Piero , Pinchera Aldo , Elisei Rossella

BRAFV600E is the most common mutation in papillary thyroid carcinoma (PTC). Anatomo-patology and clinical features of PTC with BRAFV600E are well described in literature.Aim of this study was to examine the prognostic significance of BRAFV600E in patients with PTC and a follow-up of 15-20 years.Genomic DNA was purified from 67 paraffin-embedded tumoral tissue. A PCR-SSCP analysis of exon 15 of BRAF ...