Searchable abstracts of presentations at key conferences in endocrinology

ea0019p31 | Clinical practice/governance and case reports | SFEBES2009

Bisphosphonate-induced hypocalcaemia on patient with malignancy induced hypercalcaemia

Abouglila Kamal , Ullah Arif

We report two cases of severe hypocalcaemia developed after intravenous administration of pamidronate in patients with severe hypercalcaemia secondary to multiple myeloma. Both of them develop symptomatic hypocalcaemia few days after treatment. Both patients was probably vitamin D deficient (both serum 25-hydroxyvitamin D level was low less than 15 (NR 25–120 nmol/l) because of a combination of poor oral intake, inadequate sunlight exposure, and the development of renal f...

ea0021p188 | Endocrine tumours and neoplasia | SFEBES2009

Ovarian Leydig cell tumour in a peri-menopausal woman with severe hyperandrogenism and virilisation

Ullah Arif , Abouglila Kamal , Ibrahim Ibrahim

We present the case of a 50-year-old woman who presented with 12 months of amenorrhea associated with signs of virilisation. Investigations revealed markedly raised serum concentrations of testosterone (9 nmol/l), whereas sex hormone binding globulin, random cortisol, androstenedione, 17-hydroxyprogesterone and dehydroepiandrosterone sulphate concentrations were all within the normal range. Computed tomography scan of the pelvis and abdomen showed a slightly bulky right ovary,...

ea0021p398 | Thyroid | SFEBES2009

Dilated cardiomyopathy and atrial fibrillation secondary to resistance to thyroid hormone

Ullah Arif , Munir Atif , Nag Sath

Background: Resistance to thyroid hormone (RTH) is a rare autosomal dominant condition of altered tissue responsiveness to thyroid hormone (TH) characterised by elevated serum FT4 and FT3 and non-suppressed TSH levels caused by mutation in the thyroid receptor (TR) β gene. Different isoforms of TR are expressed in the heart and regulate genes that encode structural and regulatory proteins. The syndrome is characterised by a variable clinical phenotyp...

ea0028p52 | Clinical practice/governance and case reports | SFEBES2012

The cost, efficacy and safety of Omnitrope compared with Genotropin in adults with growth hormone deficiency

Ullah Arif , Peacock Helen , Arutchelvam Vijayaraman , Nag Sath , Ashwell Simon

Omnitrope is a biosimilar growth hormone (GH) preparation with a lower acquisition cost than other GH preparations. We switched adult patients with growth hormone deficiency treated with Genotropin (n=14, age 59.2±13.7 [mean±SD] yrs, 8 male) to Omnitrope at an equivalent dose. There followed titration visits every month for 3 months then visits every 3 months until 9 months. GH dose (0.5±0.0 vs 0.5±0.0 mg [mean±SD],...

ea0021p334 | Steroids | SFEBES2009

A rare cause of massive bilateral adrenal enlargement complicating management of congenital adrenal hyperplasia

Nag Sath , Munir Atif , Ullah Arif , Santhakumar Anjali

A 33-year-old lady presented to the surgeons with history of abdominal pain. CT scan abdomen done revealed massive adrenal enlargements reported as adrenal myelolipomas (left gland measuring 8.0×10.9×11.8 cm and multifocal lesions on the right with the larger one measuring 5.2×4.3×3.6 cm). She was referred to the endocrinology team where further history was elicited. She had been diagnosed as a child to have congenital adrenal hyperplasia (CAH) but was lost...

ea0015p351 | Thyroid | SFEBES2008

Discrepancy between free thyroid hormones and thyrotropin values in patient with Hashimotos thyroiditis

Abouglila Kamal , Ullah Arif , Cooper Helen , Thirugnanasothy Logan , Day Julie

Background: Measurements of thyrotropin (TSH), free thyroxine (FT4) and triiodothyronine (FT3) are widely used diagnostic methods for thyroid function evaluation. However, some serum samples will demonstrate a nonspecific binding with assay reagents that can interfere with the measurement of these hormones. Few case reports of TSH interfering antibodies have described the presence of such interferences resulting in reported abnormal concentrations of thyroid hormones. Unusual ...

ea0015p354 | Thyroid | SFEBES2008

Hypo-osmolar hyponatremia and orthostatic hypotension as the chief symptom in primary hypothyroidism

Ullah Arif , Abouglila Kamal , Thirugnanasothy Logan , Cooper Helen

Background: Postural hypotension has been commonly described in elderly. Common causes include medication, fluid loss, adrenal insufficiency and autonomic dysfunction. Hyponatremia is not a disease in itself, but a manifestation of a variety of disorders and side-effects of diuretics; alternatively, it may be the only manifestation of certain disorders. We present a case of primary hypothyroidism presenting as collapse with postural hypotension and severe hyponatremia.<p c...

ea0015p355 | Thyroid | SFEBES2008

Sunitinib induced hypothyroidism in gastrointestinal stromal tumours

Cooper Helen , Abouglila Kamal , Ullah Arif , Thirugnanasothy Logan

Background: Sunitinib is a tyrosine kinase inhibitor used in the treatment of metastatic GIST and renal cell carcinoma. Tyrosine kinase receptors are involved in tumour growth, angiogenesis and metastatic invasion. It can cause hypothyroidism but few cases have actually been reported. Mechanisms suggested for the incidence of hypothyroidism include antithyroperoxidase activity,1 and blocking uptake of iodine in the thyroid gland,2 or it may induce destruc...

ea0028p358 | Thyroid | SFEBES2012

Assessment of surgical and histological outcome of grade THY3 thyroid fine needle aspiration cytology

Siddaramaiah Naveen , Ashwell Simon , Arutchelvam Vijayaraman , Nellaiappan Shunmugam , Ullah Arif , Devaraj Mamatha , Nag Sath

Background: Thyroid fine needle aspiration cytology (FNAC) is an essential component of investigating discrete thyroid nodules. Grade THY3 Cytology implies a follicular lesion and usually requires diagnostic Hemithyroidectomy. Published data from UK suggests an incidence of malignancy in the range of 25 to 28% following Thy3 cytology. Nodular size of > 40 mm is shown to be significantly associated with increased incidence of thyroid malignancy. Aim: To assess the biochemic...

ea0015p235 | Pituitary | SFEBES2008

Primary pituitary lymphoma presenting as hypopituitarism and diabetes insipidus

Ullah Arif , Abouglila Kamal , Cooper Helen , Thirugnanasothy Logan , James Andy , Lewis Joanne

Back ground: Pituitary adenomas are the most common cause of a mass in the sella, accounting for up to 10–15% of intracranial neoplasm’s1. However, when dealing with abnormal intrasellar masses, a number of different etiologies are possible: germ cell tumour, metastatic tumours, granulomatous, and inflammatory processes2. We report an unusual case of primary pituitary lymphoma diagnosed on biopsy presenting as panhypopituitarism and Diabetes Ins...