Searchable abstracts of presentations at key conferences in endocrinology

ea0013oc20 | Novartis Basic Endocrinology Award | SFEBES2007

Insulin fails to limit proteolysis in critically-ill medical patients to rates observed after cardiothoracic surgery

Whyte Martin , Jackson Nicola , Shojaee-Moradie Fariba , Beale Richard , Treacher David , Blauth Christopher , Jones Richard , Umpleby Margot

Recent data suggest that critically-ill medical patients might not obtain as much benefit from insulin therapy as cardiothoracic patients. This may be because medical patients are more insulin resistant. We have investigated this in both groups.10 medical patients (age 67.0±4.4 y; 7M:3F, BMI 24.0±1.7 kg/m2; studied within 36 hours of admission to the ICU) and 7 post-operative cardiothoracic patients (age 71.4±3.8 y; 5M:2F, BMI 2...

ea0070aep799 | Reproductive and Developmental Endocrinology | ECE2020

Investigation of the mechanism of action of duodenal mucosal resurfacing in insulin resistant women with polycystic ovarian syndrome. the DOMINO multicentre randomised controlled trial

Dimitriadis Georgios K. , Kaur Vasha , Pérez-Pevida Belen , Bansi Davinder , Jayasena Channa , Bate Danielle , Fielding Barbara , Balfoussia Danai , Webber Lisa , Miao Yun , Mears Frederick , Jackson Nicola , Coppin Lucy , Johnson Brett , Umpleby Margot , Randeva Harpal S , Miras Alexander D

Introduction: Duodenal mucosal resurfacing (DMR) is a novel therapy for T2DM. It involves the hydrothermal ablation of up to 14 cm of the duodenal mucosa through a specially designed endoscopic catheter. The procedure is performed under general anaesthesia, patients are discharged the same day and it does not involve the implantation of a foreign body. Cohort studies have demonstrated that DMR induces meaningful hbA1c reductions of 0.9–1.4% by 3 months that are largely m...