Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc4.3 | Diabetes and Obesity 1 | ECE2014

Importance of neuropeptide Y as a predictor of nephropathy in type 2 diabetic patients

Unal Asli Dogruk , Tarcin Ozlem , Takir Mumtaz , Parildar Hulya , Cigerli Ozlem , Eroglu Hacer , Demirag Nilgun Guvener

Background and aims: Neuropeptide Y (NPY) cause decrease glomerular filtration rate, aldosterone concentration, and plasma renin activity by stimulating NPY receptors in the kidney. Previous studies have suggested that NPY polymorphism is related to development of advanced diabetic nephropathy (DN). The aim of this study was to evaluate the relationship between the serum neuropeptide Y levels and different stages of DN in patients with type 2 diabetes mellitus (T2DM).<p cl...

ea0035p768 | Obesity | ECE2014

Serum orexin-A levels, insulin resistance and sleep problems in metabolic syndrome

Parildar Hulya , Cigerli Ozlem , Ergen Nilay , Tarcin Ozlem , Unal Asli Dogruk , Eroglu Hacer , Guvener Nilgun

Background and aims: Orexins are hypothalamic neuropeptides involved in energy homeostasis and sleep regulation. We aimed to find the relation between serum orexin-A levels, glucose, and insulin levels, depression and sleep problems in patients with metabolic syndrome.Materials and methods: This descriptive, cross-sectional study included 43 patients with metabolic syndrome (patient) and 16 healthy subjects (control, age, and sex matched) who applied to ...

ea0032p608 | Female reproduction | ECE2013

Vitamin D level in polycystic ovary syndrome patients is not different from healthy control in Turkish population

Unal Asli Dogruk , Tarcin Ozlem , Cigerli Ozlem , Takir Mumtaz , Parildar Hulya , Ergen Nilay , Demirag Nilgun Guvener

Introduction: Polycystic ovary syndrome (PCOS) is widely diagnosed among young women in reproductive age. Vitamin D deficiency has been known as a common problem in all ages and also in a recent study which performed in a small study groups, reported that it may accompany with hyperandrogenism. The aim of our study is to evaluate serum 25(OH)D3 levels in PCOS patients compared with healthy control and relation to androgen levels.Methods: Forty...

ea0022p364 | Diabetes | ECE2010

Evaluating the effects of vitamin D metabolism on glycemic parameters and atherosclerosis markers in prediabetic patients

Parildar Hulya , Takir Mumtaz , Unal Asli Dogruk , Cigerli Ozlem , Gulmez Oyku , Dinc Feyza , Guvener Nilgun Demirag

Background and aims: Hypovitaminosis D may be associated with metabolic parameters in addition to its well-known calcemic actions. There is increasing evidence that vitamin D metabolism affects the risk of insulin resistance although the underlying molecular mechanism of this association is not clear but on the basis of evidence it is not clear whether or not vitamin D supplementation therapy in vitamin D-deficient prediabetics affects the prevention of type 2 diabetes. Our st...

ea0022p367 | Diabetes | ECE2010

Evaluation of HbA1c levels for the detection of prediabetes

Unal Asli Dogruk , Parildar Hulya , Takir Mumtaz , Cigerli Ozlem , Dinc Feyza , Guvener Nilgun Demirag

Objective: Recent recommendations suggest that HbA1c as a stable and standardised index of chronic glucose exposure over time and could be used as a better biochemical marker for the diagnosis of diabetes and prediabetes. Our aim in this cross-sectional study is to assess the validity of HbA1c as a screening tool for the detection of prediabetes in our patient population.Methods: The study was done in 265 patients selected among the participants attended...

ea0020p143 | Thyroid | ECE2009

Clinical and epidemiological characteristics of thyroid hemiagenesis: ultrasound screening in patients with thyroid disease and normal population

Gursoy Alptekin , Anil Cuneyd , Unal Asli Dogruk , Nar Asli , Tutuncu Neslihan Bascil , Erdogan Murat Faik

Objective: Thyroid hemiagenesis is a rare form of thyroid dysgenesis, in which one thyroid lobe fails to develop. The true prevalence of this rare abnormality is about 0.05–0.2% in normal population. We aimed to determine prevalence of thyroid hemiagenesis in patients with various thyroid disorders and a normal population in a mild to moderate iodine-deficient area.Subjects and methods: The clinical and thyroid ultrasonography records of 4.833 patie...

ea0016p52 | Adrenal | ECE2008

Relation between serum adiponectin level, subclinical Cushing's syndrome and non-functional adrenal incidentaloma

Unal Asli Dogruk , Ayturk Semra , Kemal Yasemin , Tutuncu Neslihan Bascil , Demirag Nilgun Guvener

In this study we compared plasma adiponectin levels between patients with non-functional adrenal incidentaloma and subclinical Cushing’s syndrome. Our aims were to determine whether there was any difference of plasma adiponectin levels, any relation between cardiovasculer risk factors and to investigate the importance of adiponectin levels in subclinical Cushing’s syndrome patients according to non-functional adrenal incidentaloma patients. The patients referred from...

ea0037ep621 | Obesity and cardiovascular endocrinology | ECE2015

Metabolic syndrome and muscle mass

Ergen Nilay , Unal Asli Dogruk , Cigerli Ozlem , Parildar Hulya , Tarcin Ozlem , Altun Betul Ugur , Demirag Nilgun Guvener

Objective: Low skeletal muscle mass is an emerging risk factor for metabolic disorders. In this study, we aimed to evaluate the relationships between fat mass, muscle mass, muscle fat mass ratio, total fat mass, and abdominal fat mass ratio by comparing the body compositions in obese women with and without metabolic syndrome.Methods: Totally 89 obese women (mean±S.D., age 42.1±12 years, BMI 36.5±4.2%) with newly diagnosed me...

ea0037ep1284 | Clinical Cases–Thyroid/Other | ECE2015

Two cases of bullous pemphigoid induced by vildagliptin

Unal Asli Dogruk , Tarcin Ozlem , Demirci Gulsen Tukenmez , Demiralay Ebru , Mansur Ayse Tulin , Yildiz Semsi , Demirag Nilgun Guvener

Background: Bullous pemphigoid is an autoimmune blistering disease that commonly arise in elderly with increased risk for mortality and morbidity. The aetiology of this disease is not entirely clear, although a few cases have been described with dipeptidyl peptidase IV inhibitors.Case 1: A 81-year-old man presented with bullous pemphigoid after 28-month treatment with repaglinide, vildagliptin, and metformin. The patient’s condition didn’t impr...

ea0032p374 | Diabetes | ECE2013

The effects of gestational diabetes on basal metabolic rate in pregnancy

Ergen Nilay , Bulgurlu Sami Sabri , Dayan Akin , Bozat Ali Erkan , Parildar Hulya , Gebeloglu Nuray , Tarcin Ozlem , Unal Asli Dogruk , Demirtunc Refik

Introduction: The total energy expenditure in pregnancy is increased largely due to elevated basal metabolic rate (BMR) during pregnancy. The aim of this study is to evaluate the effects of gestational diabetes on basal metabolic rate, body weight and HbAlc, by comparing these parameters in gestational diabetic and healthy pregnant women.Method: Fifty-eight gestational diabetic women (GDM) and fourty healthy non diabetic pregnants who had normal thyroid ...