Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep91 | Adrenal and Cardiovascular Endocrinology | ECE2020

Composite pheochromocytoma of the adrenal gland: Case report

Nicoleta Dumitrascu Andreea , Dumitru Teodora , Preda Cristina , Ungureanu Maria Christina

Introduction: Composite pheochromocytoma is a rare tumor composed histologically of pheochromocytoma and other neurogenic tumor components such as neuroblastoma, ganglioneuroblastoma, ganglioneuroma, peripheral nerve sheath tumor, or other types of neuroendocrine carcinoma. The frequency of composite adrenal tumors reportedly ranges from <3% of all adrenal gland neoplasms to 1–9% of pheochromocytomas. The clinicopathological diagnosis of composite pheochromocytoma is...

ea0081ep712 | Pituitary and Neuroendocrinology | ECE2022

Evolution from recurrent cushing’s disease to pituitary carcinoma

Anisia Miruna , Dumitru Teodora , Stoica Alexandra , Ungureanu Maria Christina , Preda Cristina , Rotariu Daniel , Leustean Letitia

Introduction: ACTH-secreting pituitary adenomas occasionally present as aggressive pituitary tumors (APT), with invasion of surrounding structures, rapid growth, resistance to conventional therapies and multiple recurrences. In rare cases they can progress to pituitary carcinomas (PC) in several years, diagnosis being made upon the documentation of systemic or central nervous system (CNS) metastatic spread. Among pituitary carcinomas, the most common malignant subtypes are lac...

ea0081ep753 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly: a rare disease with multiple, complex complications

Istrate Andra Cristiana , Leustean Letitia , Ungureanu Maria- Christina , Teodoriu Laura , Bilha Stefana , Florescu Alexandru , Preda Cristina

Introduction: Acromegaly is a rare, challenging disease that if not appropriately treated can lead to numerous complications. Some of the most frequent complications are cardiovascular (hypertension, secondary cardiomyopathy, arrhythmias, valvulopathies, heart failure) and metabolic (secondary diabetes, various alterations of the lipid metabolisms). Aim: The aim is to asses the impact of long-term acromegaly on the cardiovascular system and glucide and l...

ea0081ep856 | Reproductive and Developmental Endocrinology | ECE2022

Nijmegen breakage syndrome with unusual presentation: a case report

Dumitru Teodora , Anisia Miruna , Andrei Diana-Cristina , Preda Cristina , Lavinia Caba , Ungureanu Maria Christina

Introduction: Nijmegen breakage syndrome(NBS) represents a rare autosomal recesive disorder, characterized by severe chromosomal instability. It is caused by mutations in the NBN gene, which product, nibrin, belongs to the hMre11/hRad50 protein complex, critical for processing DNA double-strand breaks during mitotic and meiotic recombination. The hallmarks of NBS are growth retardation, microcephaly, premature ovarian failure(POI) in females, immunodeficiency and predispositio...

ea0090ep1169 | Late Breaking | ECE2023

Distant metastasis in a female patient with thyroid and breast carcinoma with low value of Thyroglobulin. Association between thyroid and breast cancer

Teodoriu Laura , Bilha Stefana , Gafton Elena , Leustean Letitia , Ungureanu Maria-Christina , Preda Cristina , Stefanescu Cipriana

Breast cancer (BC) is the most common type of cancer and the leading cause of cancer-related death in women worldwide. A considerable number of these long-term survivors may therefore have an elevated risk of developing a second primary malignancy (SPM). Thyroid cancer (TC) is the most prevalent endocrine malignancy among women. Epidemiologic studies have indicated that patients with BC have a higher risk of developing TC as an SPM, and vice versa, than would be expected in th...

ea0063p569 | Diabetes, Obesity and Metabolism 2 | ECE2019

Body composition (DXA) and hormonal picture in obese children

Teodoriu Laura , Trandafir Laura , Ambarus-Popovici Ioana , Ioan Bianca , Ungureanu Maria-Christina , Preda Cristina

Introduction: Obesity in children is rising worldwide with premature development which could involve greater risk of complications and comorbidities in adult life. Central adiposity is a well known feature of glucocorticoid excess and there are some speculations that cortisol biosynthesis is involved in pathogenesis of metabolic syndrome. However the circadian rhythm of cortisol axis or incrimination of cortisol excess in obese children is less known. Our aim is to investigate...

ea0037ep111 | Steroids, development and paediatric endocrinology | ECE2015

The beast behind the dwarf

Rimbu Cosmina , Damian Lisandra , Leustean Letitia , Miron Ingrith , Florescu Alexandru , Vulpoi Carmen , Ungureanu Maria Christina

Abnormalities of growth are one of the most common reasons for the paediatric–endocrinology consults. It’s an obvious manifestation with countless possible causes behind, and sometimes we can have unexpected diagnosis.Case presentation: we investigated the case of a 4 years old girl, born at term, naturally, SGA: birth weight=1950 g, who presented in the Endocrinology Department for short stature. Clinical evaluation: 89.5 cm (−4 DS), 11 ...

ea0037ep1333 | Clinical Cases–Thyroid/Other | ECE2015

Potential effects of endocrine disruption: reproductive tract abnormalities in a 4 years boy

Rimbu Cosmina , Damian Lisandra , Axinte Ramona , Preda Cristina , Mogos Voichita , Ungureanu Maria Christina

Endocrine disrupting chemicals are substances, both natural and artificial to which we are all exposed, even in a low dose in our everyday life. Health effects attributed to endocrine disrupting compounds include immune dysfunctions, various cancers, neurological effects and behaviour disorders, reproductive problems, early puberty, etc. Over the past 50 years, an increase in urogenital tract abnormalities in males has been noted. We present a 4 year old boy case report, born ...

ea0070ep490 | Thyroid | ECE2020

Solitary fibrous tumour of the thyroid, features of a very rare tumour: A case report

Dumitru Teodora , Hrisa Anamaria , Nechita Mirela-Claudia , Ciobanu Delia , Danila Radu , Ungureanu Maria-Christina

Introduction: Solitary fibrous tumor (SFT) is a sporadic tumor, commonly found in the pleural cavity. It is like a large well-circumscribed mass, arising from mesenchymal tissue, with spindle cells proliferation, arranged in various patterns. SFT of the thyroid is exceptionally rare, with only about 28 cases being reported in the international literaterature.A 34-year-old woman presented in the Department of Endocrinology with the diagnosis of a multinod...

ea0032p607 | Female reproduction | ECE2013

Main determinants of serum uric acid concentrations in polycystic ovary syndrome patients

Leustean Letitia , Preda Cristina , Ungureanu Maria Christina , Cristea Cristina , Mogos Voichita , Ungureanu Didona , Vulpoi Carmen

Introduction: Uric acid may increase cardiovascular risk, exerting proinflammatory, pro-oxidant and proliferative actions at the endothelial cell level. Classic and non-classic cardiovascular risk markers cluster in women with polycystic ovary syndrome (PCOS), uric acid being proposed as one of them. The studies available at present regarding serum uric acid levels in PCOS patients are scarce and controversial. The aim of the study was to examine the relationship between uric ...