Searchable abstracts of presentations at key conferences in endocrinology

ea0063p643 | Interdisciplinary Endocrinology 1 | ECE2019

Unexpected manifestation of autoimmune thyroid disease in a lipoid proteinosis patient

Uygur Meliha Melin , Eskiocak Ali Haydar

Extracellular matrix protein 1 (ECM1) is an 85 kDa glycoprotein that plays an important role in skin physiology, angiogenesis, tumor progression and malignancies. However, the function of ECM-1 in regulation of the immune responses has not been identified. Recent studies showed ECM-1 deficiency lowers the capacity of T helper 2 (Th2) cells to emigrate from draining lymph nodes to an inflamatory site. Lipoid proteinosis (LiP) and Licken Sclerosus (LS) are immunogenetic counterp...

ea0049ep665 | Obesity | ECE2017

Decreased muscle strength is associated with vitamin D and albumin levels after bariatric surgery

Yavuz Dilek Gogas , Uygur Meliha Melin

Bariatric surgery patients are at risk of decreasing in muscle mass, vitamin and protein deficiency. The aim of this study is to asses muscle strength, serum protein and vitamin levels after bariatric surgery.Methods: 264 patients underwent bariatric surgery who completed 6 th month policlinic visits were included in the study. Patients were followed appropriately supplemented protein and vitamins as suggested; all study parameters were assessed before a...

ea0049ep676 | Obesity | ECE2017

Bone mineral density and bone turnover markers after bariatric surgery

Uygur Meliha Melin , Yavuz Dilek Gogas

Although bariatric surgery has beneficial effects on obesity related complications, rapid weight loss might have negative effects on skeletal health. The objective of our study was to evaluate changes in bone mineral density (BMD) and bone biochemical markers in patients, before and 1 year after bariatric surgery.Methods: One hundred and two morbidly obese subjects (mean 43±15 years, BMI 48,5 g/cm2) performed either Roux en Y gastric bypa...

ea0073aep540 | Pituitary and Neuroendocrinology | ECE2021

A micromegaly case: Difficult to determine whether a metabolic state or an acromegaly subset

Uygur Meliha Melin , Yavuz Dilek Gogas

Introduction:Acromegaly is caused by excess levels of growth hormone (GH) and insulin-like growth factor 1 (IGF1), which usually result from a pituitary adenoma. At the presence of classical symptoms, the diagnosis is confirmed by increased serum IGF1 concentrations and high serum levels of GH that are not suppressed in an an oral glucose tolerance test (OGTT). A nadir GH cut-off of 0.4 µg/lwith ultrasensitive assays is considered as diagnostic. How...

ea0041ep872 | Pituitary - Clinical | ECE2016

Endocrinologic outcomes of gamma knife radiosurgery for acromegaly: from an endocrine clinic

Uygur Meliha Melin , Deyneli Oguzhan , Yavuz Dilek Gogas

Although surgical resection is the usual initial treatment for patients with acromegaly, it does not always lead to a remission. Gamma knife radiosurgery (GKRS) is an important additional strategy for unresected clinically active pituitary adenomas.Objective: We evaluated retrospectively pituitary hormone status as well as the efficacy of GKRS for patients with acromegaly referred to our tertiary endocrinology clinic. Prognostic factors related to outcom...

ea0041ep915 | Pituitary - Clinical | ECE2016

Prolactin measurements improve the diagnostic accuracy of inferior petrosal sinus sampling

Uygur Meliha Melin , Yasar Mehmet , Deyneli Oguzhan , Yavuz Dilek Gogas

Introduction: Inferior petrosal sinus sampling for ACTH is the current gold standard test for the differentiation of pituitary Cushing disease from the ectopic ACTH syndrome. Early studies with ─░PSS reported a diagnostic sensitive and specificity approaching 100%, additional experience has shown a false negative rate of 1-10%. This has been due to either technical problem with unsuccessful petrosal sinus catheterization or anomalous venous drainage of the pituitary. The ...

ea0073aep471 | Pituitary and Neuroendocrinology | ECE2021

Association between fibroblast growth factor-21 and carotid intima media thickness in patients with acromegaly

Uygur Meliha Melin , Yavuz Dilek Gogas , Yazici Dilek

─░ntroductionThe aim of this study was to evaluate the association between fibroblast growth factor-21 (FGF-21) levels and carotid intima media thickness (CIMT) in acromegalic patients in relation to the atherosclerotic complications.Metarials and methodsThe study goroup included 70 acromegalic patients. According to the disease activity, patients cathegorized inti 2 groups: controlled and active acromega...

ea0049ep851 | Clinical case reports - Pituitary/Adrenal | ECE2017

Pachydermaperiostosis: a rare syndrome presented with acromegaloid changes

Uygur Meliha Melin , Arikan Izzet Hakki , Deyneli Oguzhan , Yavuz Dilek Gogas

Introduction: Pachydermoperiostosis (PDP) is a rare hereditary syndrome with familial and idiopathic forms that is characterized by subperiosteal new bone formation with pain, polyarthritis, cutis vertices grata, seborrhea, hyperhidrosis and digital clubbing. Periostosis and cutaneous thickening along with the absence of any signs of cardiovascular, pulmonary, hepatic, intestinal and mediastinal diseases causing secondary hypertrophic osteoarthropathy suggest PDP. The incidenc...