Searchable abstracts of presentations at key conferences in endocrinology

ea0097004 | Section | BES2023

Androgen Deprivation Modulates the Adrenocortical Stress Response

V. Sommers , M. Gentenaar , E. Viho , C. Helsen , V. Dubois , J. Kroon , B. Decallonne , F. Claessens , O.C. Meijer

Background and aim: Androgens and glucocorticoids are regulated via the hypothalamus-pituitary-gonadal (HPG) and hypothalamus-pituitary-adrenal (HPA) axis, respectively. We aimed to check possible interference of androgen deprivation with the HPA axis and circulating glucocorticoid levels. Androgen deprivation is most widely used in the treatment of prostate cancer, but is also applied in gender-affirming care and males with hypersexual disorder. Current insig...

ea0042oc2 | (1) | Androgens2016

Control of androgen bioactivity by sex hormone-binding globulin

Laurent Michael R , Antonio Leen , Blokland Marco H , Sterk Saskia S , Jardi Ferran , Dubois V , Kaufman Jean-Mark , Fiers Tom , Huhtaniemi Ilpo T , Hammond Geoffrey T. , Vanderschueren Dirk , Claessens Frank

Sex hormone-binding globulin (SHBG) is a high-affinity binding protein for androgens and estrogens. According to the “free hormone hypothesis”, SHBG regulates the free sex steroid fraction and restricts androgen bioactivity. SHBG has also been independently associated with diabetes, osteoporosis etc., but whether this represents causality or residual confounding remains unconfirmed. We studied mice overexpressing human SHBG. Using multiligand liquid chromatography ta...