Searchable abstracts of presentations at key conferences in endocrinology

ea0011p354 | Diabetes, metabolism and cardiovascular | ECE2006

Prevalence of registered diabetic nephropathy and its terminal stages

Gubkina VA , Misnikova IV , Dreval AV , Vetchinnikova ON

Background: Diabetic nephropathy is leading cause of end-stage renal disease (ESRD), which requires dialysis or a transplant. Progression of diabetic nephropathy (DN) leads to development of chronic renal failure (CRF).Material and methods: Data for 124 554 DM patients who live in Moscow region (MR) is in the MR DM register for 2004. The number of T1D- 8747, T2D patients is 115, 534. These registers only contain information about registered cases of DN.<...

ea0081rc3.1 | Rapid Communications 3: Thyroid 1 | ECE2022

Usefulness of the EU-TIRADS score on sparing thyroid nodules cytology: a retrospective study

Puga Francisca , Silva Vânia Benido , Carvalho Andre , Freitas Claudia

Introduction: Incidental diagnosis of thyroid nodules has increased in recent years, leading to thyroid cancer diagnosis inflation. Nonetheless, mortality rate for thyroid malignancies remains very low, suggesting that its treatment is unlikely to affect the overall prognosis in the majority of cases. Several thyroid imaging scores have been proposed to reduce unnecessary invasive diagnostic procedures. Our aim was to verify the usefulness of the EU-TIRADS score on sparing thy...

ea0011p646 | Reproduction | ECE2006

Hormonal status of women with benign endometrial hyperplastic lesions

Osipova AA , Matveeva VA , Samoilova AV , Gunin AG

Retrospective randomized blinded study was carried out to find differences in hormone levels in blood between groups of patients with normal endometrium and with endometrial benign hyperplastic lesions. Hospital cases were randomly selected from journals of admittance from 1997 to 2005 years. Only patient name, age and clinical diagnosis, in which endometrial histology was reflected, could be viewed at the time of cases selection. There were to groups of cases selected, with a...

ea0049gp38 | Bone & Calcium Homeostasis 1 | ECE2017

Decreased trabecular bone score but not bone mineral density in patients with acromegaly and concurrent hypogonadism: cross-sectional study with healthy controls

Kužma Martin , Pavai Dušan , Sagova Ivana , Killinger Zdenko , Jackuliak Peter , Vaňuga Anton , Vaňuga Peter , Payer Juraj

Introduction: Acromegaly is associated with higher prevalence of vertebral fractures (VFx) and bone microarchitecture potentially play a role in fracture development. Trabecular bone score (TBS), a novel indicator of bone microstructure could provide additional information.Objectives: Assessment of BMD, TBS and bone turnover markers (BTM) in acromegaly patients in comparison to healthy controls with regard to gender, hypogonadism and disease activity.</p...

ea0049ep1086 | Clinical case reports - Pituitary/Adrenal | ECE2017

Combination of turner syndrome and congenital adrenal hyperplasia: a rare case report

Sagova Ivana , Pavai Dušan , Stančik Matej , Urbankova Helena , Gregova Juliana , Vaňuga Anton , Vaňuga Peter

Combination of Turner syndrome (TS) and classical congenital adrenal hyperplasia (CAH) is rare worldwide. Incidence of CAH - autosomal recessive disorders characterized by enzyme defect of steroidogenic pathway, of which 90% ocuurs in the CYP21A2 gene coding 21-hydroxylase is 1:10000-16000. Incidencie of Turner syndrome is 1:2500 worldwide. Phenotypically, females with TS may present with a wide spectrum of clinical features. They may exhibit short stature, virilization, prema...

ea0081p668 | Pituitary and Neuroendocrinology | ECE2022

Ultrasound of the median nerve in acromegalic patients : changes at 1 year follow up

Sagova Ivana , Pavai Dušan , Mokaň Marian , Vaňuga Peter

Background: The aim of our study was to asses changes in the cross sectional area (CSA) of the median nerve by ultrasound in newly diagnosed acromegalic patients 1 year after treatment of acromegaly (transsphenoidal surgery, somatostatine analogues).Patients and methods: The study included 30 newly diagnosed acromegalic patients (18 females and 12 males) and 30 healthy controls (18 females and 12 males) matched for age, gender and body mass index. Clinic...

ea0070ep322 | Pituitary and Neuroendocrinology | ECE2020

Heart failure as a first manifestation of acromegaly - A case report

Sagova Ivana , Pavai Dusan , Dragula Milan , Kantarova Daniela , Vanuga Anton , Vaňuga Peter

Acromegaly is a rare disease, which is mainly caused by benign tumour of the pituitary gland. Long-term presence of elevated growth hormone (GH) and insulin like growth factor 1 (IGF-1) levels accompanying this disease is associated with rheumatologic, cardiovascular, pulmonary and metabolic complications. Cardiovascular complications of acromegaly include a cardiomyopathy, arterial hypertension, arrhytmias, valvulopathy as well as endothelial dysfunction. Cardiovascular disea...

ea0011p377 | Diabetes, metabolism and cardiovascular | ECE2006

Frequency of dyslipidemiαs in children – results of lifestyle intervention

Petrou VA , Tertipi AK , Posnaghidou E , Kostakioti ED , Skarpa VT , Anastasakou M , Hadjiathanasiou C

Dyslipidemiαs should be managed from childhood for prevention of early atheromatic vascular lesions and premature cardiovascular disease in adult life.Aim: We examined the frequency of different types of dyslipidemiα in children and the results on blood lipids of lifestyle intervention (diet and exercise).Patients and methods: We studied retrospectively 136 children, 74 boys and 62 girls, mean chronological age 8.5±3...

ea0081ep286 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Age-related changes in proinsulin processing in non-diabetic individuals

Vaňkova Marketa , Vejražkova Daniela , Lukašova Petra , Včelak Josef , Bendlova Běla

Introduction: To understand the pathological changes associated with glucose homeostasis in old age, it is necessary to know the natural changes in the processing of proinsulin into mature insulin. Surprisingly, while there is abundant information about insulin function in diabetics, the situation in healthy adults and old humans was rarely examined.The study aimed: To determine how the proinsulin secretion in individuals with normal glucose tolerance ch...

ea0063p1022 | Interdisciplinary Endocrinology 2 | ECE2019

Influence of type 2 diabetes on androgen levels in women with Alzheimer’s disease

Vaňkova Marketa , Vacinova Gabriela , Hill Martin , Včelak Josef , Vejražkova Daniela , Bendlova Běla

Introduction: Alzheimer’s disease (AD) is a neurodegenerative disease that is manifested by progressive loss of cognitive function. Neuroactive steroids and their metabolites have an important regulatory role in the nervous system, affect neuronal plasticity, response to stress, learning and memory and have a neuroprotective effect. One of the not fully elucidated risk factors for AD is impaired glucose tolerance/type 2 diabetes (T2D). It is well known that lower androgen...