Endocrine Abstracts

Background: Genetic deficiency of the hypothalamic hormone kisspeptin, lead to pubertal failure and infertility. Kisspeptin is therefore a critical hypothalamic activator of reproduction. Kisspeptin-10 stimulates gonadotrophin release in both male and female rodents. However few studies have investigated the effects of kisspeptin-10 on gonadotrophin release in humans, and none have investigated its effects in women. If kisspeptin is to be useful for treating reproductive disea...