Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc8.4 | Oral Communications 8: Calcium and Bone | ECE2022

Is the “rebound phenomenon” following Denosumab discontinuation a risk factor for Zoledronic acid acute phase adverse reactions?

Zampogna Marta , Grassi Giorgia , Ghielmetti Alberto , Palmieri Serena , Arosio Maura , Vainicher Cristina Eller

Background: Zoledronic acid (ZOL) administration may cause acute phase adverse reactions (APR), which manifest with fever, malaise, bone and muscular pain, headache and/or gastrointestinal disturbances. Previous data suggest that high N-terminal propeptide of type 1 collagen (P1NP) and low 25, OH-vitaminD (VitD) levels are associated with higher incidence of APR, while the previous use of bisphosphonates is a protective factor. Lately, ZOL has been frequently used to mitigate ...

ea0081p558 | Calcium and Bone | ECE2022

Clinical and biochemical response to Burosumab treatment in two patients with X-linked hypophosfatemic rickets and tertiary hyperparathyroidism

Ghielmetti Alberto , Zampogna Marta , Palmieri Serena , Grassi Giorgia , Rosa Caruso Maria , Arosio Maura , Vainicher Cristina Eller

Introduction: in X-linked hypophosfatemic rickets (XLH) mutations of PHEX lead to elevated FGF-23 levels. Phosphate salts and calcitriol represented the only treatment option. Tertiary hyperparathyroidism (THPT) is a complication of XLH worsening the clinical features and constituting a contraindication to conventional treatment. Burosumab, a monoclonal antibody anti-FGF23, was recently approved in XLH. No data about Burosumab treatment in patients with XLH and THPT are availa...

ea0016p130 | Clinical cases | ECE2008

A fetus affected with a complete androgen insensitivity syndrome due to a novel mutation of AR and persistent Mullerian structures

Vainicher Cristina Eller , Muzza Marina , Gaetti Luigi , Fugazzola Laura , Bulfamante Gaetano , Spada Anna Maria

Complete androgen insensitivity syndrome (CAIS) is a rare X-linked disorder caused by androgen receptor gene (AR) mutations that result in complete impairment of genital virilisation. Usually CAIS patients, who have normal production of AMH by Sertoli Cells, do not show Mullerian derivatives, although the persistence of Mullerian duct derivatives up to now have been described in nine cases.Here, we report the case of a fetus aborted at 20 weeks for genit...

ea0022p7 | Adrenal | ECE2010

Beneficial metabolic effects of surgical treatment in patients with an adrenal incidentaloma causing subclinical hypercortisolism

Chiodini Iacopo , Morelli Valentina , Salcuni Antonio Stefano , Vainicher Cristina Eller , Torlontano Massimo , Coletti Francesca , Iorio Laura , Cuttitta Antonello , Ambrosio Angelo , Vicentini Leonardo , Pellegrini Fabio , Copetti Massimiliano , Beck-Peccoz Paolo , Arosio Maura , Ambrosi Bruno , Trischitta Vincenzo , Scillitani Alfredo

Objective: In patients with adrenal incidentalomas (AI) the metabolic effect of the recovery of subclinical hypercortisolism (SH) is debated. The aim of this study was to determine the effect of the surgical and conservative approaches on the metabolic syndrome in AI patients with and without SH.Patients: One hundred and eight AI patients were studied; SH was diagnosed in the presence of >2 out of: urinary free cortisol >70 μg/24 h (193 nmol...