Searchable abstracts of presentations at key conferences in endocrinology

ea0041s7.2 | The chronic syndromes of patients with cured pituitary diseases (<emphasis role="italic">Endorsed by the European Journal of Endocrinology</emphasis>) | ECE2016

Cushing’s disease: 10 years after cure

Valassi Elena

Recent evidence suggests that resolution of hypercortisolism in Cushing’s disease (CD) may not lead to complete remission of the clinical abnormalities associated with this condition. In particular, elevated cardiovascular risk may persist in ‘cured’ CD patients long-term after eucortisolism has been achieved. This is believed to be related with the maintenance of visceral obesity and altered adipokine secretory pattern which perpetuate features of metabolic syn...

ea0070aep589 | Pituitary and Neuroendocrinology | ECE2020

The cushing’s collaborative patient survey results

Valassi Elena , Tabarin Antoine , Chiodini Iacopo , Feelders Richard , Andela Cornelie

Background: Early diagnosis of Cushing’s syndrome and initiation of effective treatment are essential to limit long-term morbidity and early mortality. However, diagnosis is often delayed due to the non-specificity of symptoms, or because symptoms are not recognised by physicians, leading to more complex treatment needs and a worsening of patient quality of life. A survey was conducted to better understand the patient experience of Cushing’s syndrome and the true b...

ea0063p729 | Pituitary and Neuroendocrinology 2 | ECE2019

Muscle dysfunction is associated with poor quality of life in patients with Cushing’s syndrome long-term after remission

Martel Luciana , Bascunana Helena , Cuartero Jordi , Biagetti Betina , Webb Susan M. , Valassi Elena

Background: Residual morbidity in patients with Cushing’s syndrome (CS) in remission significantly affects Quality of Life (QoL). While sustained muscle weakness is a frequent complaint in these patients, the impact of muscle dysfunction on their psychophysical wellbeing is currently unknown. Patients & methods: We included 28 female patients [mean(±SD) age, 50±12 years; mean (±SD) BMI, 26.7±3.8] and 26 age- and BMI-matched healthy controls. Mean (...

ea0049gp36 | Bone &amp; Calcium Homeostasis 1 | ECE2017

Relationship between circulating microRNAs and bone mineral density in patients with active acromegaly

Valassi Elena , Garcia-Giralt Natalia , Malouf Jorge , Crespo Iris , Webb Susan M.

Objective: Acromegaly (ACRO) is associated with abnormal bone remodeling and reduced volumetric bone mineral density (vBMD) at the lumbar spine and proximal femur. Circulating microRNAs (miRNAs) modulate the activity of osteoblasts and osteoclasts, and are currently being investigated as potential biomarkers of osteoporosis. The aims of our study were: 1) To identify differentially expressed miRNAs in the serum of five patients with active ACRO vs. healthy controls, and 2) To ...

ea0041ep17 | Adrenal cortex (to include Cushing's) | ECE2016

Psychopathology, memory and quality of life in Cushing’s syndrome

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Maria Antonia , Pires Patricia , Webb Susan

Introduction: Cushing’s syndrome (CS) has been related to higher psychopathology. Psychopathology can be related to poor memory performance, and low quality of life. The aim of this study is to establish the relationship between the three parameters and with subjective symptom perception in CS.Methods/design: Thirty six patients in remission of CS and 36 matched controls for age, sex and education years were included in the study. They completed SCL...

ea0056p852 | Pituitary - Clinical | ECE2018

Psychopathology in Cushing’s disease and acromegaly

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Webb Susan M

Introduction: Cushing’s disease (CD) and acromegaly, despite their different specific symptoms, often present psychopathology (mainly depression and anxiety) even after hormonal normalization. However, their psychopathological profiles may be different. The aim of this study was to analyse the psychopathological profile in successfully treated Acromegaly and CD, and to compare both diseases. Current hormonal evaluation and time since endocrine control will also be analyse...

ea0081rc13.8 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Gut dysbiosis in patients with cushing’s syndrome in remission. relationship with cardiometabolic risk

Valassi Elena , Manichanh chaysavanh , Martel Duguech Luciana Maria , Gonzalez Fernandez Pedro , Gaztambide Sonia , Puig-Domingo Manel , Webb Youdale Susan

Background: Patients with Cushing’s syndrome (CS) in remission show residual cardiometabolic derangements leading to increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis), such as richness, diversity and composition, have been associated with several cardiometabolic risk factors, including obesity, insulin resistance and atherosclerosis. Whether CS patients present with intestinal dysbiosis is currently unknown. Our study was aimed at evalu...

ea0081p254 | Late-Breaking | ECE2022

Facial phenotype changes and its impact in Quality of Life of acromegaly patients

Ferrer Laura , Antonia Martinez-Momblan Maria , Marques-Pamies Montse , vazquez Federico , Soldevila Berta , Ciriza Raquel , Valassi Elena , Puig-Domingo Manel

Acromegaly is a rare disease usually diagnosed late in disease evolution. It implies for skeletal changes of most flat bones including those of the skull. Consequently, a progressive facial disfiguration occurs at slow velocity of irreversible nature. Even after curation most of these changes stay for the whole life of the patient.Aim: to study the potential relationship between disfiguring facial modifications and psychosocial and Quality of Life (QoL) ...

ea0037ep64 | Adrenal cortex | ECE2015

Serum brain-derived neurotrophic factor in Cushing's syndrome patients

Santos Alicia , Resmini Eugenia , Barahona Ma Jose , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Marin Ana , Webb Susan M

Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that has been linked to several cardiovascular risk factors and bone status. Stress and corticosteroid exposure can affect BDNF levels, although this has never been studied in Cushing’s syndrome (CS). The aims of this study were to establish if BDNF levels were reduced in CS and to check possible associations to cardiovascular risk factors and bone status.Methods: 52 patients (18 ac...

ea0037ep798 | Pituitary: clinical | ECE2015

Increased serum levels of the Wnt antagonist Dicckopf-1 (DKK1) and impaired trabecular bone mineral density using QCT scan in acromegalic patients

Valassi Elena , Crespo Iris , Aulinas Anna , Urgell Eulalia , Malouf Jorge , Llauger Jaume , Marin Ana Maria , Biagetti Betina , Webb Susan M

Introduction: Acromegaly is associated with increased bone turnover and skeletal fragility. Although the GH/IGF1 system plays an important role in bone homeostasis, effects of GH excess on the Wnt signalling pathway are to be determined. Bone quantitative CT (QCT) provides a volumetric, tridimensional measure of bone mass at the trabecular and cortical level.Aim: i) To compare volumetric bone density (vBMD) using QCT in patients with acromegaly vs gender...