Endocrine Abstracts

Introduction: Medullary thyroid cancer is a rare neoplasm, accounting for approximately 4% of all cases of thyroid cancer. Exceptionally, it can be associated with the hormonal production of ACTH or CRH, causing ectopic Cushing’s syndrome.Clinical Case: We present the case of a 43-year-old man who, as a history of interest, presented a T6-T8 vertebral body fracture 2 years ago and a right hip fracture 1 year ago. Bone densitometry is compatible with...

Introduction: Morbid obesity is a highly prevalent disease, with bariatric surgery being a fundamental pillar in its treatment.Objectives: To analyze the results of weight loss at 5 years in patients operated by gastric bypass and sleeve at the Regional University Hospital of Malaga.Methods: This is a retrospective observational study, where 104 patients with morbid obesity who underwent bariatric surgery at the Regional University...

Rationale: Patients with morbid obesity may have vitamin D deficiency and bariatric surgery may exacerbate it due to factors such as lack of dietary compliance, reduced intake, malabsorption, etc.Objective: To study vitamin D deficiency prevalence in patients with morbid obesity before and after bariatric surgery and its relationship with other laboratory parameters.Methods: A retrospective study of 88 morbidly obese patients befor...

Aim: To analyze the influence of bariatric surgery over serum lipids in patients with morbid obesity after 1 year of surgery.Methods: Retrospective study of 88 patients before and after 1 year of bariatric surgery (65 by pass and 23 sleeve). We collected data about age, sex, other diseases, anthropometric measures and biochemical parameters: glucose, uric acid, total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), VLDL and non-HDL-C, homocistein and ...

Introduction: Ghrelin is a gastrointestinal peptide involved in the regulation of body weight and energy balance. However, its behavior after bariatric surgery and its relationship with other biochemical variables is still under discussion. We aim to undertake a simultaneous evaluation of the changes in ghrelin levels after three types of bariatric surgery and its relationship with different variables.Design: The study included 21 non-obese and 103 morbi...

Introduction: Thyroid dysfunction is a common health problem. Its prevalence may vary in different populations, and in Spain, it has not been sufficiently studied. The aim of this study was to evaluate the prevalence of thyroid dysfunction (clinical and subclinical) in our country.Materials and methods: The diabetes study is a national, cross-sectional, population-based survey. Target population: the entire Spanish population >18 years. Sample: >...

Objective: To study the association between the state of iodine nutrition, and the risk of total and cause mortality in a representative sample of the Spanish adult population.Design: Longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the national study [email protected] (2008–2010). We used ...

Introduction: Epigenetic is acquiring great importance in complex diseases, providing mechanisms whereby environmental factors can influence complex diseases such as obesity and type 2 diabetes. Experimental animal and human studies have revealed the association between SCD1 and obesity and insulin resistance. The aim of this study was to evaluate whether metabolic changes after intervention are associated with DNA methylation pattern and if these changes are related to weigh ...

Introduction: Obesity is associated to a pro-inflammatory state with a different pattern of response from the classical response. Also, obesity is associated to non-alcoholic fatty liver disease (NAFLD). In this sense, natural killer T (NKT) cells are a subset of innate immune cells that abundantly reside within the liver and are readily activated by lipid antigens. However, the phenotype and functional characteristics of these cells are no clear in the immune homeostasis in o...

Introduction: The stearoyl-CoA desaturase 1 (SCD1) is an enzyme involved in the metabolism of fatty acids, and seems to be involved in the regulation of atherosclerosis development. In this study we want to check the expression of SCD1 in visceral and subcutaneous adipose tissue and its relationship with the metabolic syndrome.Methods: We measured SCD1 mRNA and protein expression in visceral and subcutaneous adipose tissue from 25 morbidly obese patients...