Searchable abstracts of presentations at key conferences in endocrinology

ea0032p690 | Neuroendocrinology | ECE2013

Iron overload impairs the migratory ability of a model of immature and migratory GnRH neurons

Steffani Liliana , Nitto Francesca Di , Macchi Chiara , Dongiovanni Paola , Rametta Raffaella , Valenti Luca Vittorio , Fargion Silvia , Magni Paolo , Ruscica Massimiliano

Iron represents a micronutrient for cellular metabolism and aerobic respiration, and is essential for proper brain development in the fetal and early neonatal period. However, excess iron produces toxic build-up via free radical formation. In thalassaemic and juvenile hemochromatosis patients with pubertal failure, iron overload interferes with the correct function of the hypothalamic–pituitary axis, leading to hypogonadotrophic hypogonadism and growth failure, but the me...

ea0032p514 | Endocrine tumours and neoplasia | ECE2013

Characterization and sub-cellular localization of somatostatin receptors in DU-145 and PC-3 human androgen-independent prostate cancer cells: effect of mono- and bi-specific somatostatin analogs on cell growth

Ruscica Massimiliano , Arvigo Marica , Steffani Liliana , Gatto Federico , Albertelli Manuela , Culler Michael D. , Valenti Luca , Minuto Francesco , Macchi Chiara , Ferone Diego , Magni Paolo

Somatostatin (SRIF) is an inhibitory hormone that plays a regulatory role in several cell functions including cell proliferation. SRIF acts through five specific membrane receptors (sst1-5), expressed on SRIF-target cells. SRIF and ssts may play a significant role in the progression and neuroendocrine differentiation of human prostate cancer (PCa). However, conflicting results have been reported in the literature on ssts heterogeneity and specific cell localization in PCa. Aim...