Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep615 | Endocrine-Related Cancer | ECE2022

Frequency of CYP1B1 gene polymorphism in obese and non-obese women with hormone-dependent endometrial cancer

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...

ea0022p135 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Insulin secretion and HOMA-IR in patients who underwent coronary angiography

Isailovic Tatjana , Petakov Milan , Ognjanovic Sanja , Macut DJuro , Popovic Bojana , Bozic Ivana , Elezovic Valentina , Damjanovic Svetozar

Introduction: Several population-based studies have shown that hyperinsulinemia and insulin resistance could be an independent predictive factor for development of coronary artery disease (CAD).Aim: The aim of this cross-sectional study was to analyze insulin secretion in patients with proven coronary artery disease.Methods: We have analyzed 151 consecutive patients (35–79 years old, men 68%, women 32%) referred for coronary a...

ea0022p243 | Clinical case reports and clinical practice | ECE2010

Nesidioblastosis in adult patient with neurofibromatosis type1 and synchronous multicentric duodenal somatostatinomas - case report

Ognjanovic Sanja , Petakov Milan , Macut Djuro , Isailovic Tatjana , Elezovic Valentina , Popovic Bojana , Bozic Ivana , Damjanovic Svetozar

Somatostatinomas are rare neuroendocrine tumors of the pancreas and small intestine that can occur sporadically or in a syndromic form. Duodenal somatostatinomas are often associated with neurofibromatosis type1 (NF1). Their presenting features are mostly related to local effects of the tumor mass rather than functional clinical syndrome. Nesidioblastosis is extremely rare cause of persistant hyperinsulinemic hypoglycaemia in adults.We present a case of ...

ea0022p439 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Cushing’s syndrome, clinicaly non-functioning pituitary adenoma and hypercalcemia

Elezovic Valentina , Isailovic Tatjana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Popovic Bojana , Bozic Ivana , Damjanovic Svetozar

A 25-year-old female, referred because of left hemianopsy, weight gain, fatigue, muscle weakness, and secondary amenorrhea. Physical examination revealed overt Cushingoid features and left temporal hemianopsy. Previously the diagnosis of pituitary macroadenoma (MRI) with suprasellar, infrasellar, and right parasellar propagation was made in regional hospital. Laboratory results showed moderate hypercalcemia with hypophosphatemia and hypercalciuria with inappropriately normal P...

ea0022p505 | Growth factors | ECE2010

Serum IGF1 levels in adult patients with type 1 Gaucher disease

Petakov Milan , Suvajdzic Nada , Petakov Marijana , Macut Djuro , Ognjanovic Sanja , Elezovic Valentina , Djurovic Marina , Damjanovic Svetozar

Background/aims: Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues including liver. It has been shown that chronic diseases with liver involvement might cause IGF1 deficiency. The aim of the study was to assess the IGF1 system in adult patients with type 1 Gaucher disease with and without enzyme replacement therapy (...

ea0020p202 | Endocrine tumours and neoplasia | ECE2009

A National survey of neuroendocrine lung tumors

Popovic Bojana , Isailovic Tatjana , Bozic Ivana , Macut Djuro , Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Damjanovic Svetozar

Neuroendocrine lung tumors represent approximately 20% of all lung tumors. They range from low-grade well-differentiated NETs and well-differentiated neuroendocrine carcinomas (typical and atypical carcinoids) to aggressive poorly differentiated small-cell and large-cell neuroendocrine carcinomas. They can develop different clinical syndromes due to ectopic hormone secretion.We analyzed 178 patients with neuroendocrine tumors (age range: 17–79 years...

ea0020p212 | Endocrine tumours and neoplasia | ECE2009

Pancreatic neuroendocrine tumors: a national survey

Isailovic Tatjana , Popovic Bojana , Petakov Milan , Ognjanovic Sanja , Macut Djuro , Bozic Ivana , Elezovic Valentina , Da Svetozar

Pancreatic neuroendocrine tumors (PETs) occurs in approximately 1 per 100 000 people per year and account for only 1–2% of all pancreatic tumors. Most of them are hormonally active, while about 30% secrete no detectable hormons and are discovered due to a tumor mass effect.Material and methods: We analysed 178 patients with neuroendocrine tumors (NETs) treated at our department in the last five years. The diagnosis was made by pathohistological exam...

ea0020p659 | Reproduction | ECE2009

Adiponectin levels and its relation to indices of insulin resistance in women with PCOS

Bozic Ivana , Macut Djuro , Popovic Bojana , Isailovic Tatjana , Ognjanovic Sanja , Petakov Milan , Elezovic Valentina , Damjanovic Svetozar

Objectives: Insulin resistance and hyperinsulinaemia are implicated in the pathogenesis of the polycystic ovary syndrome (PCOS) in the majority of the cases. Adiponectin is adipose tissue-specific protein and its correlation with insulin resistance is well established. The aim of the study was to access the correlation between adiponectin and anthropometric and metabolic parameters in a group of women with PCOS.Methods: Thirty-one women with PCOS (age: 2...

ea0081rc13.4 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Analysis of the body composition and glucose metabolism in relation to bcli glucocorticoid receptor polymorphism in women with adrenal incidentalomas

Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Elezovic Valentina , Antic Jadranka , Opalic Milica , Radic Lena , Macut Djuro P

Single nucleotide polymorphisms in the glucocorticoid receptor (GR) gene influence tissue sensitivity of GR. Several studies have shown different effects of BclI GR polymorphism on body composition and metabolic parameters. The objective of this study was to explore the effect of BclI GR polymorphism on the body composition and glucose metabolism. Biochemical tests and hormonal evaluation were performed in 106 consecutive women with adrenal incidentalomas (AI...

ea0081p665 | Pituitary and Neuroendocrinology | ECE2022

Long-term follow up after remission of Cushing’s disease - experience of a single centre

Popovic Bojana , Ognjanovic Sanja , Ilic Dusan , Elezovic Valentina , Opalic Milica , Radic Lena , Milicevic Mihailo , Macut Djuro P.

Introduction: Chronic endogenous hypercortisolism in Cushing’s syndrome imposes a great clinical burden of comorbidities, some of which might persist even after disease remission. Our aim was to analyze factors that predict long-term comorbidities after surgical remission of Cushing’s disease (CD).Subjects and methods: We retrospectively analyzed 37 patents (91.9% females) aged 39.5±13.9 years (10-70) with diagnosed CD, treated in our inst...