Searchable abstracts of presentations at key conferences in endocrinology

ea0075m08 | Metabolic Bone | EYES2021

Safety and efficacy of PTH 1-34 and 1-84 therapy in chronic hypoparathyroidism: a meta-analysis of prospective trials

Hasenmajer Valeria , Puliani Giulia , Sada Valentina , Tarantino Chiara , Lenzi Andrea , Isidori Andrea

Introduction: Hypoparathyroidism is the only endocrine deficiency for which replacement therapy with the missing hormone is not part of the clinical practice. High quality evidence on the use of PTH 1-34 or PTH 1-84 in hypoparathyroidism is missing.Objective: We aim to evaluate the efficacy and safety of PTH 1-34 and PTH 1-84, and to compare the two treatments when possible.Methods: We searched databases up to March 2021 for random...

ea0090p278 | Adrenal and Cardiovascular Endocrinology | ECE2023

Bone metabolism and dual-release Hydrocortisone: results from a real-life study

Ferrari Davide , Sada Valentina , Hasenmajer Valeria , De Alcubierre Dario , Puliani Giulia , Minnetti Marianna , Cozzolino Alessia , Bonaventura Ilaria , Tomaselli Alessandra , Pofi Riccardo , Lenzi Andrea , M. Isidori Andrea

Background: Patients with adrenal insufficiency (AI) require long-term glucocorticoid (GC) replacement therapy and generally show an increased prevalence of bone metabolism alterations. Only few data are available on bone safety of dual-release Hydrocortisone (DR-HC) therapy.Objective: To evaluate bone metabolism in both primary AI (PAI) and secondary AI (SAI) during long-term therapy with DR-HC.Methods: We studied patients with AI...

ea0090p555 | Adrenal and Cardiovascular Endocrinology | ECE2023

Coagulation parameters in patients with adrenal incidentalomas and mild cortisol secretion: sex difference matters

Bonaventura Ilaria , Minnetti Marianna , De Alcubierre Dario , Tomaselli Alessandra , Ferrari Davide , Sada Valentina , Angelini Francesco , Hasenmajer Valeria , Cozzolino Alessia , Sbardella Emilia , Pofi Riccardo , Lenzi Andrea , Isidori Andrea M.

Background: Patients with CushingÂ’s syndrome (CS) typically show an alteration in the intrinsic coagulation pathway, leading to an increased risk of venous thromboembolism. Cortisol autonomy has been variably associated with higher risk of cardiovascular events and mortality compared to patients with non-functioning adrenal adenomas (NFA), particularly in women younger than 65 years. However, dedicated studies describing coagulation status in patients with adrenal inciden...

ea0090p423 | Pituitary and Neuroendocrinology | ECE2023

Immune profile in acromegalic patients and the impact of the current medical treatment. Resultsfrom the PROMISE study

Feola Tiziana , De Alcubierre Dario , Sada Valentina , Puliani Giulia , Sciarra Francesca , Cozzolino Alessia , Appetecchia Marialuisa , Sbardella Emilia , Jaffrain-Rea Marie-Lise , Anna Venneri Mary , Isidori Andrea

Context: Acromegaly is associated with several metabolic and cardio-respiratory comorbidities, with a relative increase in the last years of cancer mortality. Although the GH/ IGF-1 axis has long been supposed to play a role on immune modulation, immune function in acromegaly is poorly known.Objective: This observational, prospective, single site, pilot study (NCT05069324) aims to analyse peripheral blood mononuclear cells (PBMCs) subpopulations in acrom...

ea0075p11 | Pituitary and neuroendocrinology | EYES2021

Pituitary adenoma consistency is associated with postoperative hormonal deficits: a retrospective study on 50 patients undergoing transsphenoidal adenomectomy

De Alcubierre Dario , Pofi Riccardo , Sbardella Emilia , Puliani Giulia , Hasenmajer Valeria , Sada Valentina , Zaccagnino Antonella , Ruggeri Andrea G. , Gianfrilli Daniele , Isidori Andrea M.

Background: Little is known about possible predictors for hormonal function following pituitary surgery. Tumor consistency has recently emerged as a key factor in surgical planning for pituitary adenomas, influencing both the surgical outcome and the onset of postoperative complications. However, its impact on postoperative endocrine function has yet to be explored.Objectives: To evaluate the impact of tumor consistency on the development of postoperativ...