Endocrine Abstracts

Background: Patients with Klinefelter’s syndrome (KS) present a high prevalence of osteopenia, osteoporosis and fragility fractures. Several factors may contribute to skeletal fragility, e.g. hypogonadism, derangements in vitamin D metabolism, reduced testicular secretion of Insulin-like Factor 3. However, phosphate metabolism has never been investigated.Methods: A retrospective analysis was conducted to investigate prevalence and characteristics of...

Introduction: Testosterone replacement therapy (TRT) in male hypogonadism aims at restoring physiological plasma testosterone (T) levels. According to current guidelines, gel formulations should resemble better the circadian T secretion and offer physiological and consistent T concentrations. However, only a few real-life studies have assessed intra-individual reproducibility of T levels in patients treated with gel formulations.Methods: Thirty patients ...

Introduction: The effects of testosterone on coagulation have not yet been clarified. In particular, it is still controversial whether male hypogonadism, or testosterone replacement therapy (TRT), may slightly increase the risk of venous thromboembolism, in particular during the first months of therapy. This study aimed to assess the hemostatic balance in hypogonadal men before and after short-term TRT, compared to healthy controls.Methods: Thrombin gene...