Searchable abstracts of presentations at key conferences in endocrinology

ea0070oc5.2 | Thyroid | ECE2020

Overtreatment of papillary thyroid microcarcinoma: a snapshot from the italian thyroid cancer observatory

Ramundo Valeria

Background and Aim: The incidence of papillary thyroid microcarcinoma (mPTC) has dramatically increased in the last decades. The majority of these tumors remain small and clinically silent, only small number progress. Clinical practice guidelines currently suggest avoiding the cytological examination of subcentimeter nodules and reducing surgeries for mPTC. Several risk factors have been identified as strongly associated with a high-risk phenotype for mPTCs (e.g. gross nodal m...

ea0070aep1062 | Hot topics (including COVID-19) | ECE2020

The emotional outbreak of (endocrine) cancer patients during COVID-19 pandemic

Falcone Rosa , Grani Giorgio , Ramundo Valeria , Melcarne Rossella , Giacomelli Laura , Filetti Sebastiano , Durante Cosimo

Background: The 2019 coronavirus disease (COVID-19) pandemic is a public health emergency and raises the issue of psychological and physical resilience in more vulnerable patients. We investigated the emotional impact of the SARS-CoV-2 spread among cancer patients, followed at our Institution in Italy, after the restrictive measures imposed by the government and the disruption of planned clinical activities.Methods: From March 18th to April 1st, 2020, we...

ea0032s31.3 | Clinical impact of rare mutations in endocrinology | ECE2013

Genetic diagnosis of hereditary neuroendocrine syndrome in asyntomatic patients: clinical and prognostic implications

Faggiano Antongiulio , Ramundo Valeria , Marciello Francesca , Del Prete Michela , Marotta Vincenzo , Colao Annamaria

Neuroendocrine tumours (NETs) can be sporadic or can arise in complex hereditary endocrine disorders such as multiple endocrine neoplasias (MENs), familial paragangliomatosis (FPGLs), neurofibromatosis type 1 (NF1), von Hippel–Lindau disease (VHL), tuberous sclerosis (TSC). It has been estimated that hereditary NET occurrence varies with site of origin of the tumour, representing 5–30% of all cases of NET. These rates seems to be an underestimation and novel mutation...

ea0026p73 | Endocrine tumours and neoplasia | ECE2011

68Ga-DOTATATE PET shows a better diagnostic performance than octreoscan in patients with neuroendocrine tumors

Faggiano Antongiulio , Aloi Luigi , Caraco Corradina , Ramundo Valeria , Severino Rosa , Lombardi Gaetano , Colao Annamaria , Lastoria Secondo

Background and objective: 111In-DPTA-Octreotide (Octreoscan) has limited spatial resolution and a somewhat lower receptor affinity of the radiopeptide compared to DOTATATE, a novel somatostatin analogue, which can be radiolabelled with 68Ga and adapted for PET imaging, resulting in an increased spatial resolution. The aim of this study was to evaluate the diagnostic performance of 68Ga-DOTATATE PET in patients with NET and to compare this tecni...

ea0026p274 | Pituitary | ECE2011

Recent changes in clinical presentation and therapeutic approach in MEN1-related pituitary adenomas

Ramundo Valeria , Severino Rosa , Milone Francesco , Lombardi Gaetano , Colao Annamaria , Faggiano Antongiulio

Background and objective: Pituitary adenomas (PAs) affect about half of the patients with multiple endocrine neoplasia type 1 (MEN1); in the most of cases PA is a PRL-oma and generally more aggressive than the sporadic form. The aim of this study is to evaluate the recent changes in clinical presentation and therapeutic approach of MEN1-related PAs.Patients and methods: The study population included 17 patients with MEN1-related PA followed-up between 19...

ea0026p530 | Bone/calcium/Vitamin D | ECE2011

Recent changes in clinical presentation and therapeutic approach of primary hyperparathyroidism in MEN1 patients

Severino Rosa , Ramundo Valeria , Milone Francesco , Lombardi Gaetano , Colao Annamaria , Faggiano Antongiulio

Introduction and aim: Primary hyperparathyroidism (PHP) is the most frequent endocrine abnormality in MEN1 affecting about 100% of cases and inducing severe bone and kidney complications. Although surgery represents the only curative approach in MEN1 PHP, novel drugs are now available to effectively control PHP. The objective of this study was to show the recent changes in clinical presentation and therapeutic approach in MEN1-related PHP occurred in the last years.<p clas...

ea0022p406 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Clinical and prognostic implications of the genetic diagnosis of hereditary NET syndromes in asymptomatic patients

Faggiano Antongiulio , Ramundo Valeria , Milone Francesco , Severino Rosa , Lombardi Gaetano , Colao Annamaria

Context: Neuroendocrine tumors (NETs) are rare neoplasms, heterogeneous, with variable biological behaviour. NETs can be sporadic or they can arise in complex endocrine hereditary syndromes such as Multiple Endocrine Neoplasias (MEN), Familial Paragangliomatosis (FPGL), Neurofibromatosis type 1 (NF1), von Hippel-Lindau Disease (VHL), Tuberous Sclerosis (TSC) and Carney Complex (CC). By performing genetic screening, patients with hereditary NETs can be identified before the dev...

ea0014p383 | (1) | ECE2007

Efficacy and safety of radiofrequency thermal ablation in the treatment of thyroid nodules with pressure symptoms in elderly patients

Faggiano Antongiulio , Di Somma Carolina , Milone Francesco , Ramundo Valeria , Lombardi Gaetano , Coloa Annamaria , Spiezia Stefano

Background: Nodular goiter is one of the commonest endocrinopathy. Its incidence increases with age accounting for more than 50% of subjects older than 60 years. Elderly subjects more frequently suffer from pressure symptoms. Loco-regional treatments, like laser photocoagulation and percutaneous ethanol injection, are a potentially useful tool to treat TNs but their efficacy is still debated. Radiofrequency thermal ablation (RTA) has been applied to several benign and malignan...

ea0070aep995 | Thyroid | ECE2020

Performance of a dual-component molecular assay in cytologically indeterminate thyroid nodules

Sponziello Marialuisa , Verrienti Antonella , Pecce Valeria , Abballe Luana , Grani Giorgio , Ramundo Valeria , Fadda Guido , Brunelli Chiara , Durante Cosimo , Filetti Sebastiano

Background: Deciding whether patients with a cytologically indeterminate thyroid nodule should be referred for surgery or for active surveillance is an important challenge for clinicians. The aim of this study was to evaluate the performance of a novel dual-component molecular assay as an ancillary molecular method for resolving indeterminate thyroid nodule cytology.Methods: We selected 156 thyroid nodules from those that had undergone both FNA cytology ...

ea0022p405 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Cinacalcet hydrochloride effectively controlled primary hyperparathyroidism in patients unresponsive to bisphosphonates

Faggiano Antongiulio , Somma Carolina Di , Milone Francesco , Ramundo Valeria , Rota Francesca , Vuolo Laura , Guerra Ermelinda , Colao Annamaria

Context: Until now the role of medical therapy in patients with primary hyperparathyroidism (PHP) was mainly based on the use of bisphosphonates. Recently, cinacalcet hydrochloride was reported to be effective in control hypercalcemia in PHP. The aim of this study was to evaluate the efficacy of cinacalcet in PHP patients who were not effectively controlled with alendronate.Patients and methods: Fourteen PHP patients (mean age 64.1±2.6) were include...