Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.04.04 | Steroids | ECE2015

Regulation of lipogenesis in human hepatocytes by androgens, glucocorticoids, and 5α-reductase

Nikolaou Nikolaos , Nasiri Maryam , Parajes Sylvia , Krone Nils , Mastorakos George , Valsamakis George , Hughes Beverly , Taylor Angela , Bujalska Iwona , Gathercole Laura , Tomlinson Jeremy

Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the commonest cause of liver cirrhosis and leading indication for liver transplant worldwide. It is tightly associated with obesity and type 2 diabetes, yet the precise mechanisms that drive its aetiology are not fully defined. Dysregulation of both glucocorticoid and androgen metabolism has been implicated in its pathogenesis. The availability of these hormones to bind and activate their receptors is mainly regulat...

ea0056oc14.2 | What is new in gestational and type 1 diabetes? | ECE2018

Profiling of activation patterns of placental mTOR in pregnancies complicated by gestational diabetes mellitus

Papadopoulou Anna , Valsamakis George , Thymara Irini , Laryngaki Anastasia , Theodorou Spyridoula , Grammatopoulos Dimitris , Papaevangelou Vasiliki , Mastorakos George

The mammalian target of rapamycin (mTOR) is a serine kinase that couples energy and nutrient abundance to cell growth and is critically involved in the onset and progression of diabetes, cancer and ageing. Placental mTOR is involved in nutrient sensing and transfer to the fetus. Animal models suggest that placental mTOR is upregulated in pregnancies complicated by gestational diabetes (GDM). Our aim was to characterize expression, and cellular localization of mTOR and whether ...

ea0034p363 | Steroids | SFEBES2014

Androgen receptor over expression drives lipid accumulation in human hepatocytes

Nikolaou Nikolaos , Nasiri Maryam , Gathercole Laura , Castro Silvia Parajes , Krone Nils , Valsamakis George , Mastorakos George , Tomlinson Jeremy

Non-alcoholic fatty liver disease NAFLD has been associated with androgen deficiency, yet in the majority of patients with non-alcoholic steatohepatitis NASH, androgens levels are normal. In contrast, women with polycystic ovarian syndrome PCOS, which is characterised by androgen excess, have evidence of increased liver fat. Our hypothesis is that androgen exposure to the liver may be crucial in the amount of lipid that can accumulate in hepatocytes. C3A human hepatoma cells w...

ea0056gp92 | Diabetes Epidemiology | ECE2018

Gestational Diabetes Mellitus is associated with increased risk of Non-Alcoholic Fatty Liver Disease: A population-based cohort study

Lavrentaki Aikaterini , Subramanian Anuradhaa , Thomas G Neil , Valsamakis George , Toulis Konstantinos , Daly Barbara , Mastorakos George , Tahrani Abd , Nirantharakumar Krishnarajah

Background: Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes, and increased risk of post-natal type 2 diabetes and cardiovascular disease. However, whether GDM increases the risk of developing incident Non-alcoholic Fatty Liver Disease (NAFLD) is unclear and has not been well examined in previous studies. This is important considering the significant health burden of NAFLD and the opportunity to interfere in high risk population in order to red...

ea0035p820 | Paediatric endocrinology | ECE2014

Anti-oxidation improves in early puberty in normal weight and obese boys, in positive association with exercise stimulated GH secretion

Paltoglou George , Fatouros Ioannis , Valsamakis George , Shina Maria , Avloniti Alexandra , Chantzinikolaou Athanasios , Kambas Antonis , Draganidis Dimitris , Mantzou Aimilia , Papagianni Maria , Kanaka-Gantenbein Christina , Chrousos George , Mastorakos George

Oxidative stress in humans has been associated with obesity. Puberty is a maturation period characterized mainly by changes of the GH and the gonadotrophin hormones secretion. To investigate the possible association of the GH and the hypothalamic–pituitary–gonadal (HPG) axes before and during early puberty, with the pro- and anti-oxidation mechanisms 76 healthy, pre-pubertal normal weight (n=28), pre-pubertal obese (n=11), early pubertal normal weig...