ea0081rc12.3 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022
Walravens Joeri
, Banica Thiberiu
, Van Den Eynde Tibbert
, Snaterse Gido
, Reyns Tim
, Narinx Nick
, Antonio Leen
, Fiers Tom
, Kaufman Jean-Marc
, Lapauw Bruno
Introduction: According to the free hormone transport hypothesis, only free testosterone (FT) is considered biologically active. Due to low circulating levels and technical challenges of direct FT measurements, calculators have been developed to estimate FT from serum total T, sex hormone-binding globulin (SHBG) and albumin levels. However, genetic polymorphisms altering SHBGs binding affinity or capacity might result in calculation imprecisions with consequent incorrect...