Searchable abstracts of presentations at key conferences in endocrinology

ea0037s5.2 | Endocrinology of ageing men | ECE2015

Osteoporosis in ageing men

Vanderschueren Dirk

Osteoporosis is still considered a postmenopausal disease. Nevertheless, about one out of three of all hip fractures occur in elderly men. Hip fractures in elderly men are also associated with considerable morbidity as well as excess mortality. However, the majority of men suffering from senile osteoporosis are still underdiagnosed and undertreated. In 2012 the endocrine society has therefore formulated practical clinical guidelines for the diagnosis as well as treatment of os...

ea0022s4.2 | The aging male | ECE2010

Osteoporosis in the aging male

Vanderschueren Dirk

Until recently, osteoporosis was considered a disease affecting mostly women. However, 30% of all hip fractures occur in men, suggesting that male osteoporosis is a major health issue as well. Low trauma fractures may also arise at other sites such as the vertebrae, distal forearm and proximal humerus. Although these osteoporotic fractures in elderly men occur less frequent than in women, mortality and disability following these fractures is greater in men than women. Beside a...

ea0073js8.2 | ESE/Clinical Guidelines of the European Academy of Andrology: Male specific endocrine conditions | ECE2021

Investigation, treatment and monitoring of functional hypogonadism in males

Vanderschueren Dirk

The focus of the new guidelines of the European academy of andrology is on functional hypogonadism since the diagnosis and treatment is more controversial than for organic hypogonadism. It is important to consider functional hypogonadism, only following formal exclusion of organic hypogonadism. Diagnosis should be made on basis of both clinical symptoms as well as the biochemical confirmation of serum repeatedly low morning fasting testosterone. Most specific symptoms are sexu...

ea0014s15.2 | Novel bone hormones and regulators | ECE2007

Hormonal regulation of periosteal bone growth

Vanderschueren Dirk , Venken Katrien

In light of the gender differences in bone geometry, sex steroids have been proposed as key regulators of pubertal periosteal bone formation. Sex steroids may affect periosteal bone apposition following activation of sex steroid receptors [androgen receptor (AR), estrogen receptor alpha (ERα) or beta (ERβ)]. Traditionally, it has been assumed that AR-mediated androgen action stimulates periosteal bone formation and thereby determines the larger bone size in males, wh...

ea0079012 | Abstracts | BES2021

The impact of anti-androgen therapy on bone in men treated for paraphilia: a retrospective cohort study

Anais De Landtsheer , Lieslinde Bekaert , Leen Antonio , Dirk Vanderschueren

Background: Guidelines suggest treating paraphilias with androgen-deprivation therapy (ADT). However little evidence is available about the long-term impact on bone and how to manage this adverse event.Aim: The aim of this study is to assess the impact of ADT on bone mass and bone mineral density (BMD) in men treated for hypersexuality with cyproterone acetate (CPA) and GnRH agonists (GnRHa), and to evaluate the effect of treatment with bisphosphonates.<...

ea0084ps1-05-44 | Miscellaneous | ETA2022

The effect of testosterone supplementation on the hpt axis in euthyroid hypogonadal adult men: a prospective observational study

David Karel , Antonio Leen , Claessens Frank , Vanderschueren Dirk , Decallonne Brigitte

Background and Objective: It is known that androgens decrease and estrogens increase TBG. In female to male transsexuals under testosterone replacement, decrease of TBG has been shown, but also an increased T3/T4 ratio despite stable free T4 and TSH, suggesting increased conversion to T3 by testosterone. We wanted to study the HPT axis in hypogonadal cis-males before and after testosterone replacement.Method: Prospective observational study in adult male...

ea0054is8 | (1) | NuclearReceptors2018

Direct and indirect effects of androgens on the musculoskeletal system

Claessens Frank , Michael Laurent , Dubois Vanessa , Khalil Rougin , Jardi Ferran , Vanderschueren Dirk

Global knockout models of the androgen receptor (ARKO) illustrates the many roles androgens and their receptor have in the development of male reproductive organs and the gender differences in many features like the musculoskeletal system. However, neither the global ARKO nor orchidectomy models discriminate between direct and indirect effects of androgens. To determine direct and indirect effects of androgens on muscle, we developed a muscle-specific ARKO (called satARKO for ...

ea0042oc11 | (1) | Androgens2016

Sex steroid deficiency alters renal calcium transporter expression independently of its effect on bone resorption

Khalil Rougin , Jardi Ferran , Laurent Michael , Claessens Frank , Vanderschueren Dirk , Decallonne Brigitte

It is well established that sex steroid deficiency induces bone loss, resulting in osteoporosis. Consequently, global androgen receptor knock out (ARKO) mice have trabecular and cortical osteopenia. Bone cell-specific ARKOs however, have a much less pronounced bone phenotype, suggesting that androgens have an influence on processes in other systems or organs which in turn have an impact on bone metabolism. The kidney is a likely candidate, as it plays an important role in calc...

ea0037gp.11.05 | Calcium, Vitamin D and Bone (1) | ECE2015

Determination of reference values for serum total 1,25-dihydroxyvitamin D3 using an extensively validated 2D ID-UPLC–MS/MS method

Dirks Niek , Martens Frans , Vanderschueren Dirk , Billen Jaak , Ackermans Mariette , Endert Erik , Blankenstein Marinus , Heijboer Annemieke

1,25-dihydroxyvitamin D3, the hormonally active metabolite of vitamin D3, tightly controls calcium blood levels. An increase of 1,25-dihydroxyvitamin D3 leads to an increase in calcium concentration with calcium originating from various resources, including bone tissue. To assess a patient’s vitamin D status the precursor metabolite 25-hydroxyvitamin D3 is determined. However, measurement of 1,25-dihydroxyvitamin D is required w...