Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1818 | Thyroid cancer | ICEECE2012

Intraoperative calcitonin stimulation testing in an individualized surgical strategy of medullary thyroid cancer - primum non nocere

Obtulovicova K. , Kalis A. , Dancova K. , Pura M. , Vanuga P. , Vanuga A. , Sicak M.

Context and Objectives: The prognosis of medullary thyroid carcinoma (MTC), derived from parafollicular C-cells, depends on the completeness of the first surgical treatment. The C-cells produce calcitonin, a peptid hormone that is used as biochemical and immunohistochemical tumor marker. The aim of study was to evaluate an individualized approach to patients with C-cell disease, i.e. MTC and C-cell hyperplasia (CCH), using the intraoperative calcitonin testing-assisted surgica...

ea0011p164 | Clinical case reports | ECE2006

Importance of complex evaluation of the changes in ST-segment in ECG: case report of the patient with Addison disease and Brugada syndrome

Pura M , Vanuga P

Authors present a case report of the 25-year patient with suspicion of adrenal insufficiency (AI). Based on the clinical picture and plasma cortisol levels in low-dose 1 μg ACTH test (32.00–65.40 nmol/l, normal response >500 nmol/l) AI was confirmed. On ECG record was present deep s-wave in leads I, II, III, aVF, V5-V6 and rsŕ-shaped QRS complex in leads aVR and V1 – finding consistent with incomplete right bundle-branch block. Moreover horizontal eleva...

ea0029oc10.5 | Pituitary Clinical 2 | ICEECE2012

Once-weekly, CTP-modified hGH (MOD-4023) is effective in growth hormone deficient adults: a phase II, dose and frequency finding study

Popovic V. , Goth M. , Vanuga P. , Payer J. , Pfeifer M. , Bidlingmaier M. , Fima E.

Objective: GH replacement therapy currently requires daily injections, which may cause poor compliance and distress for patients. CTP-modified hGH (MOD-4023) is being developed for once-weekly administration in GH Deficient adults and children. The present study evaluated the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of MOD-4023 in GHD adults.Design and methods: 39 normalized GHDA patients currently treated with daily GH were randomized and...

ea0020p266 | Bone/Calcium | ECE2009

Vitamin D levels in young healtly premenopausal females in Slovakia

Vanuga P , Killinger Z , Masaryk P , Tomkova S , Kmecova Z , Spustova V , Stecova A , Payer J

Background: There is increasing body of evidence suggesting for low vitamin D levels in humans. The levels of vitamin D in nonselect populations of Europe, Middle East, Asia and Latin America had been repeatedly shown to be as low as 20-30 μg/l.Aim: The aim of our study was to examine serum 25-hydroxyvitamin D [25-(OH)D] levels in young healthy premenopausal women in Slovak population.Subjects and methods: The participants (<i...

ea0011p926 | Thyroid | ECE2006

The Gods placed the diagnosis before the therapy: case reports of the Slovak families with resistance to thyroid hormones

Vanuga P , Mendelova E , Fodor G , Vitesnik K , Savagner F , Malthiery Y , Pura M

Resistance to thyroid hormones (RTH), is with the exceptions caused by mutations in the gene coding β1-subunit of the thyroid receptor (TRβ1) located on chromosome 3. More than 700 individuals with RTH belonging to about 250 families have been identified up to date. The presence of goiter, tachycardia and hyperactivity together with abnormal findings on routine thyroid testing usually lead to further investigation and, ultimately, the diagnosis ...

ea0011p241 | Cytokines and growth factors | ECE2006

Effect of growth hormone deficiency in adults on insulin action and gene expression of selected adipokines in subcutaneous adipose tissue

Penesova A , Skopkova M , Pura M , Vlcek M , Radikova Z , Vorzakova I , Tajtakova M , Vanuga P , Belan V , Koska J , Payer J , Klimes I , Gasperikova D

Growth hormone deficiency (GHD) in adults seems to predispose to insulin resistance (IR). Development of GHD related IR could be associated with adipose tissue (AT) derived signals. To investigate the nature of this pathological regulation we 1) measured gene expressions for leptin, adiponectin, TNFalpha, IL-6, 11beta HSD1, SREBP, PPARgamma in the AT of untreated GHD adults, and 2) assessed effect of euglycemic hyperinsulinemia (HI) at the gene level.Met...

ea0022p553 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Efficacy of acromegaly treatment in six Czech and Slovak tertiary centers: first analysis of patient registry RESET (Registry of Sellar Tumors)

Hana Vaclav , Bandurova L , Brabec P , Cap J , Durovcova V , Hana V , Jarkovska Z , Kentos P , Klapka R , Klimasova K , Klimes D , Krsek M , Lazurova I , Olsovska V , Podoba J , Pura M , Siprova H , Steno J , Sticha M , Trejbalova L , Vanuga P , Wagnerova H , Weiss V , Zeman D , Dusek L , Marek J

Acromegaly is frequently diagnosed late and pituitary macroadenoma is revealed in the majority of patients. Treatment usually needs combination of several treatment modalities to suppress the disease activity. Efficacy of our treatment of acromegaly was not analysed till now.Aim: First analysis of the diagnostics of acromegaly, efficacy of treatment, its complications and status of acromegaly patients in six tertiary referral centers in the Czech Republi...