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ea0099rc12.3 | Rapid Communications 12: Diabetes, Obesity, Metabolism and Nutrition | Part II | ECE2024

Adipose tissue analysis toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue

Robino Jacob , Plekhanov Alexander , Zhu Qingzhang , Jensen Michael , Scherer Philipp , Roberts Charles , Varlamov Oleg

The pathological expansion of white adipose tissue (WAT) in obesity involves adipocyte hypertrophy accompanied by expansion of collagen-rich pericellular extracellular matrix (ECM) and the development of crown-like structures (CLS). Traditionally, WAT morphology is assessed through immunohistochemical analysis of WAT sections. However, manual analysis of large histological sections is time-consuming, and available digital tools for analyzing adipocyte size and pericellular ECM...

ea0099p497 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Western-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy and t-cell dysfunction in rhesus macaques

Burwitz Benjamin , yusova Sofiya , Robino Jacob , Takahashi Diana , Luo Addie , Slayden Ov , Bishop Cecily , Hennebold Jon , Roberts Charles , Varlamov Oleg

Hyperandrogenemia (elevated testosterone, T) and metabolic dysfunction are hallmarks of polycystic ovary syndrome (PCOS), which can have varying degrees of ovulatory dysfunction. Adipocyte hypertrophy, induced by obesity and hyperandrogenemia, has been suggested to contribute to the systemic low-grade inflammation thought to be one of the drivers leading to reproductive dysfunction in women with PCOS. However, whether hyperandrogenemia and adipocyte hypertrophy per se induce a...

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Endocrine Abstracts

Adipose tissue analysis toolkit (ATAT) for automated analysis of adipocyte size and extracellular matrix in white adipose tissue

Western-style diet in the presence of elevated circulating testosterone induces adipocyte hypertrophy and t-cell dysfunction in rhesus macaques

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