Searchable abstracts of presentations at key conferences in endocrinology

ea0029p296 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Allosteric effects between the protomers of AT1 angiotensin receptor homodimer: role of the conserved DRY motif

Szalai B. , Varnai P. , Hunyady L.

Introduction: G protein coupled receptor dimerization is proposed to have great impact on receptor signaling. Allosteric communication between the protomers of a dimer can alter ligand binding, receptor conformation and the interactions with different effector proteins. Although the concept of intradimeric interactions is widely accepted, the molecular mechanism behind them is not clearly understood. In this study we investigated the allosteric interactions within the type I a...