Searchable abstracts of presentations at key conferences in endocrinology

ea0044oc1.6 | Early Career Oral Communications | SFEBES2016

A time controlled β-cell specific mouse model Men1L/L/RIP2-CreER for pancreatic neuroendocrine tumours (NETs)

Vas Nunes Roeland P , Frost Morten , Stevenson Mark , Lines Kate E , Thakker Rajesh V

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by occurrence of parathyroid tumours and neuroendocrine tumours (NETs) of the pancreas and pituitary, which is caused by mutations of the MEN1 gene, encoding menin. Mouse models are important in elucidating mechanisms of MEN1 tumourigenesis and treatments, but the current models have limitations. Thus, in conventional heterozygous MEN1 knockout models, tumour d...