Endocrine Abstracts

Aim: To determine the relationship between C-reactive protein (CRP) and nephropathy in type 1 diabetic patients.Methods: A total of 68 patients (24 women and 44 men) with type 1 diabetes aged 46.58±12.23 years were studied. All subjects had BMI<35 kg/m2. The levels of CRP, fasting blood glucose (FBG), triglycerides (TG), HbA1c and renal function tests were assessed. Patients were divided into 2 groups: 1 group – patients with nep...

Aim: To determine the relationship between serum lipids with albuminuria in patients with type one diabetes.Methods: A total of 150 diabetic patients both sexes aged 41.58±11.33 years were studied. The levels of total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), VLDL-cholesterol (VLDL-C), HbA1c and renal function tests were assessed. Patients were classified as normoalbuminuric (albumin excretion...

There is growing evidence that platelet indices correlate with functional status of platelets and with the risk of cardiovascular events. In this study we aimed to assess clinical correlates of mean platelet volume (MPV) in patients with abdominal obesity from different age groups. We investigated 111 adults with abdominal obesity, not receiving antiplatelet therapy. Abdominal obesity was defined in accordance with IDF criteria (2006). Group 1 included 44 patients aged 26&#150...

Background: Diabetic nephropathy (DN) is a serious complication of diabetes associated with increased risk of mortality, cardiovascular and renal outcomes. Diagnostic markers to detect DN at early stage are important as early intervention can slow loss of kidney function and improve patient outcomes. The aim of our study was to evaluate the role of serum cystatin C (CysC) for early detection of kidney damages in patients with type 2 diabetes mellitus (DT2).<p class="abstex...

Background and Aims: to assess the relationship between level of interleukin-6 (IL-6) and the renal function in patients with diabetes mellitus (DM).Method: A total of 416 patients with DM, aged 34 to 75 years, were examined. Control group included 60 healthy patients the same age/All patients underwent standard clinical and laboratory examination, with an assessment of the levels of natriuretic peptides (BNP, proBNP) and level of IL-6. Renal function wa...

Objective: A diabetic state is causally related to heart failure (HF) which is a leading cause of mortality. Early detection of high-risk individuals is imperative for primary prevention. The aim of this study was to investigate the role of N-terminal pro-B-type Natriuretic Peptide (NT-proBNP) in patients with diabetes type 2 (DT2).Methods: We investigated 86 patients both sexes with DT2 aged 65.54±11.37 years (from 50 to 65 years) without clinical ...

Aim: To find early diagnostic criteria for metabolic syndrome (MS) in obese women in early pregnancy.Materials and methods: We examined 143 pregnant women aged from 19 to 43 years (31.0 (26.0; 35.0)) and divided them into three groups: MS group (n=55), risk group (one to two components of MS) (n=57), and control group (n=31). Laboratory examination included blood pressure (BP) monitoring, assessment of a lipid profile, glucose ...

Introduction: Atherosclerotic complications are the leading causes of morbidity and mortality among patients with DT2.Aim: To investigate the possible role of dyslipidaemia, hypertension and chronic kidney disease (CKD) on the characteristics of carotid atherosclerosis (presence of plaque, carotid IMT and total plaque area) in patients with DT2.Material and methods: Patients aged 60–75 years with DT2 were included in this stud...

Aim: The aim of this study was to investigate the role of C-reactive protein (CRP) in gestational diabetes mellitus.Material and methods: We studied 65 healthy pregnant women aged 29.75±5.59 years. All women referred for a 100–g oral glucose tolerance test following an abnormal result on a screening. The demographic data, waist circumference, height, and weight of the participants were recorded. Fasting levels of insulin, triglycerides (TG), CR...

Proinflammmatory cytokines including interferon gamma (IFNg) are known to be involved in the pathogenesis of diabetic nephropathy. The aim of this study was to assess serum level of IFNg and its clinical correlates in patients with type 2 diabetes and early CKD receiving different types of treatment. We investigated 64 patients with type 2 diabetes and CKD stages 1-3. Group 1 included 20 patients on insulin therapy. Group 2 included 44 patients on metformin or combined oral hy...