Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc8.4 | Reproduction 1 | ECE2019

Conditional ablation of AMP-Activated Protein Kinase (AMPK) in GnRH neurons reveals specific roles in reproductive and metabolic homeostasis

Roa Juan , Franssen Delphine , Barroso Alexia , Ruiz-Pino Francisco , Vazquez Maria Jesus , Garcia-Galiano David , Castellano Juan Manuel , Gaytan Francisco , Dieguez Carlos , Pinilla Leonor , Lopez Miguel , Tena-Sempere Manuel

Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, the final output pathway for the brain control of reproduction, directly or indirectly receive and integrate multiple signals, including metabolic cues regulating reproductive function. Yet, the molecular underpinnings of such phenomenon remain largely unfolded. AMP-activated protein kinase (AMPK), a fundamental cellular sensor that becomes activated in conditions of energy deficit, has a key ro...

ea0037oc7.4 | Neuroendocrinology and pituitary-basic | ECE2015

Gonadotropin-inhibitory hormone signalling displays sexually dimorphic roles in the control of energy homeostasis: studies in the NPFF1 receptor null mouse

Leon Silvia , Vazquez Maria Jesus , Barroso Alexia , Garcia-Galiano David , Ruiz-Pino Francisco , Manfredi-Lozano Maria , Romero-Ruiz Antonio , Sanchez-Garrido Miguel A , Dieguez Carlos , Nogueiras Ruben , Roa Juan , Pinilla Leonor , Tena-Sempere Manuel

RF-amide-related peptide-3 (RFRP-3), the mammalian orthologue of the avian gonadotropin-inhibiting hormone (GnIH), has been proposed as major inhibitory signal for the reproductive axis, acting via the NPFF1 receptor (NPFF1R). In addition, RFRP-3 has been recently suggested to modulate feeding, with reported orexigenic actions; a function that might contribute to the integrative control of energy homeostasis and reproduction. However, characterisation of the metabolic effects ...

ea0037gp.13.04 | Diabetes and obesity – Translational cardiovascular and obesity | ECE2015

Metabolic and gonadotropic impact of sequential obesogenic insults in the female: influence of the loss of ovarian secretion

Sanchez-Garrido Miguel A , Ruiz-Pino Francisco , Manfredi-Lozano Maria , Leon Silvia , Heras Violeta , Castellano Juan M , Vazquez Maria Jesus , Roa Juan , Romero-Ruiz Antonio , Dieguez Carlos , Pinilla Leonor , Tena-Sempere Manuel

While female fertility is known to be sensitive to conditions of low body fuel reserves, the reproductive consequences of persistent energy excess remain ill defined. Yet, the pandemic proportions of obesity, and its potential impact on the gonadotropic axis, call for a better understanding of this phenomenon. Alike, the influence of ovarian hormones on the pathophysiology of obesity and its complications merits further investigation. In this work, we aimed to elucidate the me...

ea0056gp141 | Neuroendocrinology | ECE2018

Reproductive and metabolic consequences of AMP-Activated Protein Kinase (AMPK) ablation in GnRH neurons

Barroso Alexia , Franssen Delphine , Ruiz-Pino Francisco , Vazquez Maria Jesus , Garcia-Galiano David , Castellano Juan Manuel , Onieva Rocio , Rodriguez Ana Belen , Gaytan Francisco , Dieguez Carlos , Pinilla Leonor , Lopez Miguel , Roa Juan , Tena-Sempere Manuel

GnRH neurons are the final output of the brain controlling reproduction. These neurons receive information from multiple central and peripheral signals, ranging from gonadal steroids to metabolic cues and brain neuropeptides, to regulate their activity. AMP-activated protein kinase (AMPK) is an intracellular sensor, activated by energy deficiency, involved in the regulation of the cellular and whole-body energy homeostasis. Previous in vitro studies suggested the part...