Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep357 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Different steroidogenesis in patients with alzheimer’s disease and Type 2 diabetes mellitus

Vankova Marketa , Hill Martin , Vcelak Josef , Vejrazkova Daniela , Bendlova Bela

Alzheimer’s disease (AD) is a neurodegenerative diseasethat is manifested by a progressive loss of cognitive and behavioral function. In previous studies, we have constructed a predictive model for the classification of AD patients based on levels of circulating steroids and their polar conjugates.Both AD and Type 2 diabetes mellitus(T2DM) are well known to affect the levels of some steroid hormones, however, in the opposite direction, and in a gen...

ea0073aep181 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Glucagon levels in women with Alzheimer’s disease

Vankova Marketa , Vcelak Josef , Vejrazkova Daniela , Bendlova Bela

Alzheimer’s disease (AD) is a neurodegenerative disease that manifests itself in the gradual loss of cognitive and behavioral functions. In humans, glucagon is processed in pancreatic alpha cells located next to insulin-secreting beta cells, suggesting a local interaction. Glucagon is also produced in the intestinal L-cells and in small amounts in the hypothalamus. The main function of glucagon is to counteract the effects of insulin and thus maintain balanced blood gluco...

ea0081ep294 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The melatonin receptor gene polymorphism rs10830963 is not associated with significant differences in sleep patterns and biorhythms.

Vejrazkova Daniela , Chocholova Denisa , Vankova Marketa , Lukasova Petra , Vcelak Josef , Sladek Martin , Sumova Alena , Bendlova Bela

Introduction: Melatonin is a crucial hormone for controlling sleep rhythms and disruption of its natural secretory rhythmicity is considered to be one of the causes of type 2 diabetes mellitus. The MTNR1B gene encodes the melatonin receptor. Polymorphism rs10830963 in this gene shows an association with fasting blood glucose and impaired glucose tolerance. Current studies suggest that carriers of the minor allele G have a slightly shifted cycle of melatonin secretion toward a ...

ea0070aep864 | Thyroid | ECE2020

Multiple endocrine neoplasia Type 1 (Men1) – genetic variants of Men1 gene in the czech population

Lukasova Petra , kuklik Miloslav , Vankova Marketa , Vondrkova Nela , Vejrazkova Daniela , Moravcova Jitka , Vcelak Josef , Bendlova Bela

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary tumor syndrome. Common manifestations include more than 20 tumors of the parathyroid, pituitary and pancreatic glands and others non-endocrine tumors. The majority of patients carry a germline mutation in a tumor-suppressor gene MEN1, that encodes nuclear protein menin, ubiquitously expressed. So fare, more than 600 germline or somatic mutations have been reported over the...

ea0056p1043 | Thyroid (non-cancer) | ECE2018

Predictive value of HLA variants for Graves’ disease recurrence – pilot study in Czech patients

Vejrazkova Daniela , Vcelak Josef , Vaclavikova Eliska , Vankova Marketa , Lukasova Petra , Bendlova Bela

Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism. The first-choice therapy is administration of thyreostatic drugs. However, approximately half of patients relapse within two years of discontinuation. It is then necessary to decide whether to re-initiate thyreostatic treatment, which may have serious side effects, or to choose a radical approach (TTE, radioiodine). Familial forms of GD indicate that the disease has a significant genetic compo...

ea0073pep2.3 | Presented ePosters 2: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The rs10830963 polymorphism of the MTNR1B gene is associated with glucose metabolism in the Czech population

Vejrazkova Daniela , Vankova Marketa , Vcelak Josef , Cirmanová Veronika , Krejčí Hana , Anderlová Kateřina , Bendlova Bela

IntroductionThe MTNR1B gene encodes a receptor for melatonin, a hormone that controls biorhythms. The gene is expressed primarily in the brain, but also in human pancreatic cells. Genetic studies suggest that variability in the MTNR1B gene is one of the factors sought to influence the pathophysiology of type 2 diabetes mellitus (T2DM). The single nucleotide polymorphism rs10830963 shows the strongest association. Our aim was to compare ...

ea0037gp.18.02 | Pituitary–Basic and IGF-1 | ECE2015

Neuroactive steroids as predictive markers for Alzheimer's disease

Vankova Marketa , Vejrazkova Daniela , Lukasova Petra , Bradnova Olga , Vacinova Gabriela , Dvorakova Katerina , Hill Martin , Vcelak Josef , Rusina Robert , Holmerova Iva , Bendlova Bela

Background and aims: Neuroactive steroids and their metabolites play an important regulatory role in the nervous system affecting the neuronal plasticity, stress response, learning, and memory. The aim of the study was to compare the steroid metabolome in AD patients and controls.Materials and methods: The study comprised of 48 AD patients (30 women and 18 men; age 73.8±9.54 years) and 33 matched controls (22 women and 11 men; age 68.2±5.94 yea...