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ea0050ja4 | Society for Endocrinology Journal Award - Clinical Endocrinology | SFEBES2017

Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels

Narayanaswamy Shakunthala , Jayasena Channa N , Ng Noel , Ratnasabapathy Risheka , Prague Julia K , Papadopoulou Deborah , Abbara Ali , Comninos Alexander N , Bassett Paul , Bloom Stephen R , Veldhuis Johannes D , Dhillo Waljit S

Clinical Endocrinology 2016 84 939945. DOI: 10.1111/cen.12603...

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ea0050ja4 | Society for Endocrinology Journal Award - Clinical Endocrinology | SFEBES2017

Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels

Narayanaswamy Shakunthala , Jayasena Channa N , Ng Noel , Ratnasabapathy Risheka , Prague Julia K , Papadopoulou Deborah , Abbara Ali , Comninos Alexander N , Bassett Paul , Bloom Stephen R , Veldhuis Johannes D , Dhillo Waljit S

Clinical Endocrinology 2016 84 939945. DOI: 10.1111/cen.12603...

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ea0044oc1.3 | Early Career Oral Communications | SFEBES2016

Investigating the interaction between KNDy peptides on gonadotrophin release in humans – novel findings with therapeutic importance

Narayanaswamy Shakunthala , Prague Julia K , Jayasena Channa N , Papadopoulou Deborah A , Mizamtsidi Maria , Shah Amar J , Bassett Paul , Comninos Alexander N , Abbara Ali , Bloom Stephen R , Veldhuis Johannes D , Dhillo Waljit S

Background: Hypothalamic KNDy neurons have recently been identified as key regulators of reproductive function by releasing three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin. Animal studies show they interact to control pulsatile GnRH release, which is vital for fertility. In animals, kisspeptin stimulates, NKB modulates and the opioid dynorphin inhibits GnRH pulsatility. However, the interaction of these peptides has never been studied in humans. To inve...

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Endocrine Abstracts

Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels

Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels

Investigating the interaction between KNDy peptides on gonadotrophin release in humans – novel findings with therapeutic importance

BiosciAbstracts