Searchable abstracts of presentations at key conferences in endocrinology

ea0022p679 | Obesity | ECE2010

Differential expression of proteins in omental and subcutaneous adipose tissue

Insenser Maria , Montes Rafael , Simo Rafael , Vendrell Joan , Escobar-Morreale Hector F

Background: Adipose tissue is considered a highly active metabolic and endocrine organ with important physiological functions. The evaluation of protein expression has the potential advantage of providing a global vision of the cellular pathways associated with adipose tissue dysfunction and obesity, permitting the identification of novel candidate molecules that would have not been considered of interest otherwise.Objectives: To identify proteins differ...

ea0041gp134 | Obesity | ECE2016

Prognostic factors and pathophysiology of diabetes remission after metabolic gastric bypass, sleeve gastrectomy and greater curvature plication: a randomized controlled trial

Vilarrasa Nuria , Casajoana Anna , de Gordejuela Amador R , Duran Xavier , Vendrell Joan , Fernandez Sonia , Garrido Pilar , Monseny Rosa , Pujol Jordi

Introduction: 39% of morbidly obese patients have type 2 diabetes mellitus (T2DM) and 80% of them can achieve diabetes remission after bariatric surgery. However, there are few randomized studies comparing the metabolic results of different surgical techniques and the hormonal mechanisms involved.Objective: To study and compare the improvement of T2DM and the hormonal pathways following three surgical techniques: metabolic gastric bypass (mGBP), sleeve g...

ea0056gp155 | Obesity | ECE2018

Changes in gut microbiota and metabolic profiles after sleeve gastrectomy

Puig Rocio , Pellitero Silvia , Martinez Eva , Tarasco Jordi , Moreno Pau , Vilarrasa Nuria , Vendrell Joan , Fernandez Sonia , Puig-Domingo Manel

We aimed to assess the effect of sleeve gastrectomy (SG) on the metabolic and gut microbiota profiles in non-diabetic obese patients with different grade of insulin resistance (IR).Methods: Prospective study of 22 morbid non-diabetic obese patients (77.2% women, age 47.13±9.51 years, basal BMI 45.59±4.99 kg/m2, 11 IR and 11 non-IR) undergoing SG. A fasting blood sample was collected at baseline and at 6 months post-SG for the determi...

ea0081ep318 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Role of incretins, gut microbiota and permeability in the remission of type 2 diabetes mellitus after bariatric surgery

Hernandez-Montoliu Laura , Puig Rocio , Pellitero Silvia , Vendrell Joan , Fernandez-Veledo Sonia , Guerrero Fernando , Vidal Anna , Rodriguez M. Mar , Montseny Rosa , Vilarrasa Nuria

Introduction: Bariatric surgery is an effective therapy for patients with type 2 diabetes mellitus (T2D). Many mechanisms have been proposed for its metabolic benefits, such as caloric restriction, weight loss, increased secretion of gut hormones like glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), bile acid diversion, decrease of pancreatic and hepatic fat deposits and changes in gut microbiome.Aims: Evaluate changes after surgery in gut microbiome profi...

ea0049ep76 | Adrenal cortex (to include Cushing's) | ECE2017

Clinical course of patients with adrenal incidentaloma: retrospective analysis of a single center

Serrano Ana Carolina Ruiz , Colet Ana Megia , Cortes Silvia Naf , Ortega Joan Vendrell , Muela Inmaculada Simon , Fraile Esther Solano , Alevras Theodora Michalopoulou

In the adrenal incidentaloma (AI) it is fundamental to determine functionality and benignity. The aim of this study was to evaluated the clinical, radiological and hormonal evolution of AI and compare the frequency of autonomous cortisol secretion (ACS) between American and European Guidelines.Methods: Retrospective evaluation of patients with AI referred to our service in the last 5 years.Results: 140 patients were included, 50.9%...

ea0037ep1002 | Thyroid (non-cancer) | ECE2015

Prevalence of thyroid dysfunction in Spain: diabetes study

Valdes Sergio , Maldonado-Araque Cristina , Tapia Maria Jose , Lago Ana , Perez-Valero Vidal , Goday Albert , Castano Luis , Delgado Edelmiro , Vendrell Joan , Rojo-Martinez Gemma , Soriguer Federico

Introduction: Thyroid dysfunction is a common health problem. Its prevalence may vary in different populations, and in Spain, it has not been sufficiently studied. The aim of this study was to evaluate the prevalence of thyroid dysfunction (clinical and subclinical) in our country.Materials and methods: The diabetes study is a national, cross-sectional, population-based survey. Target population: the entire Spanish population >18 years. Sample: >...

ea0056p584 | Obesity | ECE2018

Effect of gastrointestinal hormones on bone metabolism after bariatric surgery

Vilarrasa Nuria , Simo-Servat Andreu , Casajoana Anna , Guerrero-Perez Fernando , Gomez-Vaquero Carmen , Martinez Eva , Virgili Nuria , Lopez-Urdiales Rafael , Fernandez-Veledo Sonia , Vendrell Joan

Introduction: In vitro and animal studies have suggested that changes in the secretion of ghrelin, PYY, GLP-1, GLP-2 can influence bone metabolism. An increase in osteoblastic differentiation has been observed after the administration of ghrelin and GLP-1. GLP-2 has been associated with a decrease in bone resorption and PYY inversely with markers of bone formation.Objective: To analyze the association of gastrointestinal hormones with changes in...

ea0035p789 | Obesity | ECE2014

Climate and risk of obesity: study

Valdes Sergio , Maldonado-Araque Cristina , Garcia-Torres Francisca , Goday Albert , Calle-Pascual Alfonso , Castano Luis , Castell Contxa , Catala Miguel , Delgado Elias , Franch Josep , Gaztambide Sonia , Gomis Ramon , Menendez Edelmiro , Ortega Emilio , Vendrell Joan , Soriguer Federico , Rojo-Martinez Gemma

Introduction: It has been suggested that the lack of exposure to low ambient temperatures may be a contributor to the development of obesity. The aim of this study was to study possible associations between climate and the risk for obesity in the Spanish population using an ecological focus.Methods: The Study is a national epidemiological study designed to determine the prevalence of diabetes, obesity and other cardiovascular risk factors in Sp...

ea0056p108 | Clinical case reports - Thyroid/Others | ECE2018

Syndrome carney-stratakis, new mutation report: SDH B: D138Y (c.412>T)

Serrano Ana Ruiz , Ciccia Alessandra Gabillo , Maduena Francisca Martinez , Gonzalez Salome Martinez , Ambros Josep Oriola , Simon-Muela Inmaculada , Ortega Joan Vendrell , Cortes Silvia Naf , Alevras Theodora Michalopoulou , Colet Ana Megia

Introduction: The Carney-Stratakis syndrome (CSS) is an inherited condition caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C or D that predispose to gastric stromal tumors (GIST) and multicentric paragangliomas (PGL). SDH acts as a tumor suppressor gene, and enzyme activity reduction is known to be oncogenic. Since 2002 there has been some scarce reports. We present a new case of CSS associated with a germline unknown significance mutation in exon 4 ...