Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep855 | Pituitary - Basic | ECE2016

Biguanides: A new potential therapeutic option for pituitary tumors?

Vazquez-Borrego Ma Carmen , Ibanez-Costa Alejandro , Venegas-Moreno Eva , Galvez Ma Angeles , Soto-Moreno Alfonso , Castano Justo P. , Luque Raul M.

Pituitary adenomas (PA) comprise a commonly underestimated pathology in terms of incidence and associated morbimortality. Somatostatin and dopamine analogs constitute the main medical treatment for PA. However, an appreciable subset of patients are resistant or poorly responsive to these drugs, and hence, the search for new therapies to control tumor growth and/or hormone secretion is crucial. Biguanides such as metformin (MF; commonly used to treat type-2 diabetes), phenformi...

ea0070aep658 | Pituitary and Neuroendocrinology | ECE2020

Prevalence of non-alcoholic fatty liver disease in patients with Cushing disease (CD)

Remon Pablo , Venegas-Moreno Eva , Deniz-Garcia Alejandro , Millan Raquel , Dios-Fuentes Elena , Martin Natalia , Rico Maria C , Madrazo Ainara , Romero-Gómez Manuel , Soto-Moreno Alfonso

Introduction: The prevalence and comorbidities of NAFLD in CD are unknown. There is only one study wich set the prevalence of NAFLD by CT images in 20%1.Objectives: Describe the prevalence of NAFLD and fibrosis in CD and analize predictive biomarkers of NAFLDMethods: Transversal descriptive study. 31 patients with CD; 11 active, 20 cured. Women 24 (77%), men 7 (23%). 54 years mean age. NAFLD was valorated by Hepatic Stea...

ea0067o34 | Oral Presentations | EYES2019

Splicing machinery is dysregulated in pituitary neuroendocrine tumors (PitNETs) and associated with aggressiveness features

Jimenez-Vacas Juan M , Vazquez-Borrego Mari C , Fuentes-Fayos Antonio C , Venegas-Moreno Eva , Gadelha Monica R , Galvez-Moreno Maria A , Soto-Moreno Alfonso , Gahete Manuel D , Castano Justo P , Luque Raul M

Objective and methods: Recent studies suggest that altered alternative splicing and, consequently, appearance of an abnormal splicing pattern and even of aberrant/oncogenic splicing-variants, represent a common molecular feature of most tumor pathologies, including Pituitary Neuroendocrine Tumors (PitNETs). However, the putative alteration, pathophysiological role and potential therapeutic utility of splicing machinery components [i.e. spliceosome-components (SCs) and splicing...

ea0049ep929 | Pituitary - Basic | ECE2017

Potential role of biguanides and statins in the treatment of pituitary adenomas

Vazquez-Borrego Mari C. , Fuentes-Fayos Antonio C , Ibanez-Costa Alejandro , Blanco-Acevedo Cristobal , Venegas-Moreno Eva , Galvez-Moreno Maria A , Soto-Moreno Alfonso , Castano Justo P. , Luque Raul M.

Pituitary adenomas (PA) comprise a commonly underestimated pathology in terms of incidence and associated morbimortality. To date, somatostatin and dopamine analogs represent the main medical treatment, but an appreciable subset of patients are resistant or poorly responsive to these drugs. Therefore, the search for new approaches to control tumor growth and/or hormone secretion is crucial. Biguanides such as metformin (MF; commonly used to treat type-2 diabetes), phenformin (...

ea0044p157 | Neuroendocrinology and pituitary | SFEBES2016

Use of biguanides in the treatment of pituitary adenomas, an in vitro approach

Ibanez-Costa Alejandro , Carmen Vazquez-Borrego Ma , Fuentes-Fayos Antonio C. , Venegas-Moreno Eva , Galvez Ma Angeles , Soto-Moreno Alfonso , Kineman Rhonda D. , Castano Justo P. , Luque Raul M.

Pituitary adenomas (PA) comprise a commonly underestimated pathology in terms of incidence and associated morbi-mortality. Although somatostatin analogs and dopamine antagonists constitute the main medical treatments for PAs, an appreciable subset of patients are resistant or poorly responsive to these drugs and hence is crucial the search for new therapies. Biguanides such as metformin (MF; commonly used to treat type-2 diabetes), phenformin (PF) and buformin (BF) have been s...

ea0037ep701 | Pituitary: basic and neuroendocrinology | ECE2015

Clinical and molecular differences between invasive and non-invasive pituitary adenomas

Cano David , Mendez-Muros Mariola , Venegas-Moreno Eva Maria , Gros Noelia , Dios Elena , Garcia-Hernandez Natividad , Madrazo-Atutxa Ainara , Martin Ignacio , Cardenas Eugenio , Kaen Ariel , Roldan Florinda , Soto-Moreno Alfonso

Pituitary adenomas are usually benign. However, a significant number of pituitary adenomas show an aggressive behaviour, with local invasion, increased risk of recurrence after surgery and lack of therapeutic response. In this study, we aimed to determine whether invasive and non-invasive pituitary adenomas display differences in clinical features and molecular parameters. In this retrospective descriptive study, 46 pituitary adenomas were analysed. Invasiveness was defined as...

ea0070aep684 | Pituitary and Neuroendocrinology | ECE2020

Evaluation of somatostatin and dopamine receptor expression in nonfunctioning pituitary adenomas

Cano Gonzales David , Flores-Martinez Alvaro , Venegas Moreno Eva , Dios Elena , Remon Pablo , Deniz-Ruiz Alejandro , Madrazo-Atutxa Ainara , Luque Raul M. , Castaño Justo P. , Soto-Moreno Alfonso

Introduction: Non-functioningpituitary adenomas (NFPAs) are of benign nature but a sizeable number of NFPAs show aggressive features. Surgery is not always effective in treating NFPAs and thus other therapeutic options are needed. Previous studies have reported that NFPAs express somastostatin receptors (SSTRs) and dopamine receptors (DRDs).Aim: To systematically analyze the expression of SSTRs and DRDs in a large cohort of clinically well-characterized ...

ea0070aep687 | Pituitary and Neuroendocrinology | ECE2020

Endoscopic transsphenoidal pituitary surgery (ETPS) for pituitary tumors: Outcomes and complications

Venegas-Moreno Eva , Remon Pablo , Dios-Fuentes Elena , Deniz-Garcia Alejandro , Cardenas Eugenio , Kaen Ariel , Martin-Schrader Ignacio , Gonzalez-Rivera Natividad , Roldan Florinda , Cano-Gonzalez David , Soto-Moreno Alfonso

Methods: Restrospective descriptive study of patients who underwent ETPS for pituitary adenoma removal performed by the same surgical team in Virgen del Rocio Hospital of Seville from January 2014 to January 2019.Results: 174 patients had a pituitary adenoma (44 GH, 36 ACTH, 94 Non functioning). 54.02% were female. In acromegaly, 39 (88.63%) patients were operated by ETPS as initial approach. 20 (51.28%) patients had cavernous sinus invation. At outcome ...

ea0056gp196 | Pituitary Basic | ECE2018

E-cadherin expression is associated with the response to somatostatin analogues in patients with acromegaly

Cano David A , Venegas-Moreno Eva , Gros-Herguido Noelia , Dios Elena , Flores-Martinez Alvaro , Gonzalez Natividad , Madrazo-Atutxa Ainara , Cardenas Eugenio , Kaen Ariel , Castano Justo P , Luque Raul M , Soto-Moreno Alfonso

Aim: To assess whether E-cadherin expression levels in somatotropinomas were associated with the response to somatostatin analogues (SSAs) therapy in patients with acromegaly.Methods: In this retrospective study, 56 acromegaly patients that underwent transsphenoidal surgery were evaluated. All patients were treated preoperatively with SSAs (octreotide or lanreotide) for at least 6 months. Responsiveness to SSAs was evaluated by percent IGF-1 reduction af...

ea0056p755 | Neuroendocrinology | ECE2018

Ki67 as a marker of recurrence in craniopharyngioma

Jesus Martinez Ortega Antonio , Maria Venegas Moreno Eva , Elena Dios Fuentes Maria , Jesus Remon Ruiz Pablo , Javier Marquez Rivas Francisco , Kaen Ariel , Cardenas Ruiz-Valdepenas Eugenio , David Cano Gonzalez Antonio , Manuel Soto Moreno Alfonso

Craniopharyngiomas (CP) are low-prevalent tumors characterized for their local invasiveness and poor clinical outcomes, often requiring aggressive therapeutic measures. Ki67 is a marker of proliferation with good correlation with tumor recurrence in many solid tumors but this relationship is unclear in CP. Our aim is to determine whether Ki67 could be a marker for recurrence in CP.Material and methods: Descriptive retrospective observational study. All p...