Endocrine Abstracts

We present a unique case of Pembrolizumab induced adrenal insufficiency. A 65 year old lady was admitted with septic shock secondary to chest infection. She was 3 weeks post neo adjuvant chemotherapy plus immunotherapy for triple receptor negative solitary Right sided breast cancer. She has Type II Diabetes mellitus, hypercholesterolemia and varicose veins. She takes Metformin and Atorvastatin. She is single, with no significant family history. On intravenous antibiotics her b...

A 52-year-old gentleman was referred for the evaluation of hypercalcaemia. He gave a four week history of feeling generally unwell with dizziness, abdominal discomfort, weight loss, nausea and vomiting. He was an ex-heavy smoker and was on Lithium for about 20 years for bipolar disorder. He had had a recent admission to hospital with sepsis, secondary to chest infection, with a brief ITU stay and was discharged only 3 weeks prior to the onset of current illness.<p class="a...

Androgen secreting ovarian tumours account for 0.1% of ovarian tumours. They can appear at any age (mean, 42 years) and can be slow growing.We report a case of androgen secreting ovarian tumour diagnosed at a delayed stage. It is unusual as it evaded diagnosis because of various factors, which we believe should be learning lesions.A 56-year-old lady with medical history of sub-arachnoid haemorrhage (SAH), presented with features of...

A 34-year-old primi gravida, 11 weeks into pregnancy, presented with hypertension (blood pressure 170/110 mmHg) proteinuria and hypokalaemia. She gave a 6-week history of tiredness, weight gain, and easy bruising. On examination, there was marked facial puffiness, non pitting oedema, thin skin with multiple bruises, marked proximal myopathy and no pigmented striae. Pregnancy associated Cushing’s was suspected.Investigations: Hypokalaemia (K+</s...

Background: Hypogonadotropic hypogonadism (HH) is commonly associated with morbidly obesity. Gynaecomastia is associated feature of hypogonadism and can be deteriorated by testosterone therapy.History: A 49-year-old gentleman with a BMI of 53.2 kg/m2 was referred for management of obesity. He has two children (age 18 and 22). He had obesity associated comorbidities including obstructive sleep apnoea and impaired fasting glucose. He reported le...